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Process of preparing burdock glucoside and glucosidgen thereof

A technology of arctiin and arctium, which is applied in the field of preparation of arctiin and its aglycone, can solve the problems of difficult solvent layering control, high cost of solvent extraction, etc., to avoid difficult operation, high purity, and strong operability Effect

Inactive Publication Date: 2006-11-15
大连权健中药饮片有限公司
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

The cost of solvent extraction is high, and the control of solvent stratification is difficult

Method used

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Effect test

Embodiment 1

[0016] The burdock fruit medicinal material is crushed into a coarse powder, heated and refluxed with 10 times the amount of petroleum ether to degrease twice, the residue is evaporated to the full extent of petroleum ether, and then extracted twice with 10 times the amount of 70% ethanol for 2 hours each time, filtered, and the filtrates are combined. Concentrate under reduced pressure until there is no alcohol smell. The obtained liquid extract is separated by polyamide with 1 times the amount of the medicinal materials, washed with water first, and then eluted with 30-70% ethanol, the ethanol eluate is concentrated under reduced pressure, and vacuum-dried to obtain the extract of arctiin and its aglycones. The yield is 5-15%, and the content of the two reaches 40-95%.

Embodiment 2

[0018] The extract is prepared by applying the preparation method of arctiin and its aglycon in the present invention. The content determination method of arctiin and its aglycone is as follows:

[0019] The content determination method of arctiin is determined according to the method under the "Chinese Pharmacopoeia" 2005 edition Arctium subitem, and the determination conditions are: reversed-phase ODS column; mobile phase is: MeOH-H 2 O (1:1.1); UV280 detection. The theoretical plate number should not be less than 1500 based on the arctiin peak. The reference substances of arctiin and its aglycone were self-made in this laboratory. The external standard method is used for quantification, and the content of the two is 40-95%.

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Abstract

A process for preparing arctiin and arctigenin used to prepare meticines features that the liquid extract of arctium fruit passes through a polyamid column for separating and purifying.

Description

(1) Technical field [0001] The invention relates to a medicine extraction and preparation method, in particular to a preparation method of arctiin and its aglycone. The method described in the present invention refers to a method for separating and purifying arctiin and its aglycone from the burdock fruit extract liquid through a polyamide column. (2) Background technology [0002] Burdock fruit is the fruit of Arctium lappa L, a plant of Compositae, which is distributed all over my country. Arctium burdock is recorded in the previous editions of "Chinese Pharmacopoeia", and has the effects of dispelling wind-heat, clearing the lungs and clearing rash, detoxifying and relieving sore throat. It is clinically used to treat wind-heat and cold, cough with excessive phlegm, measles, rubella, sore throat, mumps erysipelas, carbuncle and sore, etc. Our research results show that arctiin and its aglycon are the active ingredients of Arctium chinensis for clearing away heat and rel...

Claims

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Application Information

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IPC IPC(8): C07H15/20A61K31/365A61K31/7028A61K36/28A61P9/12A61P31/02A61P31/12C07D307/20
Inventor 窦德强康廷国李墨
Owner 大连权健中药饮片有限公司
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