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Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing

A technique of nerve growth factor, composition, applied in the field of pain treatment by administering nerve growth factor antagonist and NSAID and compositions containing them, capable of solving problems of tolerance and addiction, limitation of therapeutic use, corrosion, etc.

Inactive Publication Date: 2006-11-29
RINAT NEUROSCI CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first category includes nonsteroidal anti-inflammatory drugs (NSAIDs), which are used to treat minor pain, but whose therapeutic use is limited by adverse gastrointestinal effects such as gastric erosion, formation of digestive Ulcerative or duodenal inflammation, and colonic and renal toxicity
The second class includes opioid analgesics such as morphine, which are used to treat moderate to severe pain, but their therapeutic use is limited due to adverse effects such as constipation, nausea and vomiting, respiratory Inhibition, confusion, renal colic, tolerance to long-term use, and risk of addiction

Method used

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  • Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing
  • Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing

Examples

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Embodiment 1

[0191] Anti-NGF monoclonal antibody combined with NSAID in the treatment of postoperative pain

[0192] We evaluated the efficacy of an anti-NGF antibody in combination with an NSAID (ibuprofen) using a pain model simulating postoperative pain. For each experiment, 16 male adult Sprague Dawley rats (Harlan; Indianapolis, IN) weighing 200 to 200 g were fed ad libitum with food and water in a room under normal light conditions for at least 1 week prior to use. After 2 hours of acclimatization in the laboratory prior to surgery, rats were divided into two groups: one group received antibody 15 hours before surgery and the other received vehicle (5% dextrose / 0.45% saline USP) at that time. Anti-NGF antibody antagonist 911 was administered at 1 mg / kg body weight (see, Hongo et al., Hybridoma 19:215-227 (2000)). All animals were administered ibuprofen at various concentrations (sc) of 10, 200 and 300 mg / kg 24 hours after surgery.

[0193] The surgery was based on the method descri...

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Abstract

The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application Serial No. 60 / 448,823, filed February 19, 2003, and U.S. Provisional Application Serial No. 60 / 448,853, filed February 19, 2003, the contents of which are incorporated by reference in their entirety . field of invention [0003] The present application relates to methods and compositions for the prevention and treatment of pain by administering to a patient a nerve growth factor antagonist in combination with an NSAID. Background of the invention [0004] Some treatments including the administration of non-steroidal anti-inflammatory drugs (NSAIDs) are currently recommended for pain relief. Administration of NSAIDs has been shown to exhibit pain-reducing features. However, treatment with NSAIDs is known to have disadvantages, including unwanted side effects such as gastrointestinal irritation and renal and hepatotoxicity. Furthermore, NSAIDs, even a...

Claims

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Application Information

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IPC IPC(8): A61K39/395
Inventor D·L·谢尔顿G·J·韦尔加拉C·M·洛
Owner RINAT NEUROSCI CORP
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