Synergistic therapeutic compositions and methods

A technology of composition and therapeutic effect, applied in the field of composition for treating congestive heart failure

Inactive Publication Date: 2006-12-20
PFIZER INC
View PDF11 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Before the present invention, there is no simultaneous use of renin inhibitors and ACE inhibitors to achieve a synergistic antihypertensive effect or any other synergistic therapeutic effect (such as using a certain amount of renin inhibitors and ACE inhibitors to achieve The effect of treating congestive heart failure)
[0007] Furthermore, prior to the present invention, the simultaneous use of a renin inhibitor with an AII antagonist, the simultaneous use of an ACE inhibitor with an AII antagonist, or the combination of a renin inhibitor with an ACE inhibitor and an AII has not been used or contemplated. Reports of simultaneous use of antagonists to achieve synergistic therapeutic effects (such as synergistic antihypertensive effect or synergistic treatment of congestive heart failure)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synergistic therapeutic compositions and methods
  • Synergistic therapeutic compositions and methods
  • Synergistic therapeutic compositions and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The term "synergistic" used herein means that at the amount used in the present invention, the effect achieved by the method and composition of the present invention is greater than the sum of the effects achieved by using the same doses of the above-mentioned inhibitors and antagonists respectively.

[0010] According to the present invention, first, a certain amount of renase inhibitor and ACE inhibitor can obtain a synergistic therapeutic effect, if the amount is administered alone, the effect cannot be achieved, and the synergistic effect is better than that of each inhibitor The total effect achieved by separate administration is greater. Preferred therapeutic effects in accordance with the present invention are the on-demand reduction of blood pressure and the treatment of congestive heart failure in mammals. The administration method of the renase inhibitor and the ACE inhibitor can be administered sequentially or simultaneously, preferably simultaneously. For s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this invention relates to synergistic compositions comprising amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an angiotensin II antagonist, which inhibitors and antagonists are present in amounts sufficient to cause synergistic therapeutic effects such as lowering blood pressure and treating congestive heart failure in a mammal. Further, this invention relates to methods for achieving synergistic therapeutic effects such as lowering blood pressure and treating congestive heart failure in a mammal which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an agiotensin II antagonist, in amounts sufficient to achieve a synergistic therapeutic effect.

Description

technical field [0001] The present invention relates to compositions and methods having therapeutic effects in mammals such as lowering blood pressure and treating congestive heart failure. More specifically, the present invention relates to synergistic compositions comprising at least two therapeutic agents selected from the group consisting of renase inhibitors, angiotensin I converting enzyme inhibitors and angiotensin II antagonists, Wherein the inhibitor and antagonist are used in an amount sufficient to produce a synergistic therapeutic effect on mammals such as lowering blood pressure and treating congestive heart failure. In addition, the present invention also relates to a method for obtaining a synergistic therapeutic effect on mammals such as lowering blood pressure and treating congestive heart failure, the method comprising at least two selected from the group consisting of renase inhibitors, angiotensin I converting enzyme inhibitors The therapeutic with the ang...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/401A61K38/55A61P9/12A61P9/04A61K31/40A61K31/00A61K31/535A61K45/06A61P9/00A61P9/10
CPCA61K45/06A61K31/535A61P9/00A61P9/04A61P9/10A61P9/12A61K31/40A61K2300/00
Inventor 安东尼·A·福萨
Owner PFIZER INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap