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Sanchi total saponin free-dried powdery injection against smash and its preparation

A technology of Panax notoginseng saponins and freeze-dried powder injection, which is applied in freeze-dried delivery, medical preparations containing active ingredients, powder delivery and other directions to achieve good safety, good stability, and stable and reliable effects of promoting blood circulation and removing blood stasis.

Active Publication Date: 2007-01-17
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, product purity and fragility become a contradiction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Produce 1,000 tubes of Panax notoginseng freeze-dried powder injection, product specification: 100mg / bottle.

[0086] Raw materials: Panax notoginseng saponins 100g (99.5%)

[0087] Mannitol 0.5g (0.5%)

[0088] Preparation:

[0089] Under the condition of 10,000 grades, get qualified injection notoginseng total saponins raw material 100g, qualified medicine and adjuvant mannitol 0.5g are dissolved in water for injection 800ml together, after activated carbon decolorization (prior art) process, Add water for injection to dilute to a total volume of 1000ml, first filter the activated carbon with fast filter paper, and filter the filtrate through filter paper and 0.4μm filter membrane for rough filtration, etc., and filter it with a filter membrane below 0.2μm under the condition of grade 100; The filtrate is sent to the packing machine, packed according to 1ml per bottle, covered with a slotted lid, sent to the freeze vacuum dryer, quickly cooled to 35°C-40°C, 2-...

Embodiment 2

[0091] Produce 1,000 tubes of Panax notoginseng freeze-dried powder injection, product specification: 150mg / bottle.

[0092] Raw materials: Panax notoginseng saponins 150g (99.3%)

[0093] Mannitol 1g (0.7%)

[0094] The preparation method is basically the same as in Example 1.

Embodiment 3

[0096] Produce 1000 tubes of Panax notoginseng freeze-dried powder injection, product specification: 250mg / bottle.

[0097] Raw materials: Panax notoginseng saponins 250g (96.2%)

[0098] Mannitol 10g (3.8%)

[0099] The preparation method is basically the same as in Example 1.

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PUM

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Abstract

A freeze-dried powder injection of arasaponin with beautiful appearance and high resistance to break is prepared from arasaponin and mannitol proportionally. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a preparation method of a freeze-dried powder injection composed of total saponins of Panax notoginseng and a small amount of mannitol and a product thereof. The product is a biomedical product with medical or health care value for blood circulation diseases. Background technique [0002] Panax notoginseng (also known as Panax notoginseng, Panax notoginseng, Southern ginseng) is a plant of the genus Araliaceae, its roots, leaves and flowers have medicinal value, mainly containing notoginseng saponins (content 2% to 14%) and other substances. Research data confirms that Panax notoginseng saponins are the active ingredients of Panax notoginseng for promoting blood circulation and removing stasis, which can effectively improve the hemodynamics of blood circulation, reduce blood viscosity, reduce blood sugar, blood lipids, and prevent the occurrence of vascular inflammation. The notoginseng saponins contained in Panax notoginseng ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/704A61K9/19A61P3/06A61P3/10A61P9/00
Inventor 杨兆祥普俊学徐树光
Owner KPC PHARM INC
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