Active endouterine contraceptive device made of composite material

An intrauterine device and composite material technology, applied in the field of female contraceptive devices, can solve the problems of complex preparation process of bare copper structure IUD, low effective utilization rate of metal copper, rough surface of metal copper, etc. Relief of various side effects, pain and bleeding

Inactive Publication Date: 2007-01-31
HUAZHONG UNIV OF SCI & TECH
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AI Technical Summary

Problems solved by technology

These side effects are related to the inherent defects of the existing copper-containing IUD or the bare copper structure of the copper-containing drug-containing IUD, such as the "burst release" of copper ions at the initial stage of insertion, the direct contact between metal copper and endometrium, and the effective effect of metal copper. The utilization rate is not high, the surface of metal copper becomes rougher, and a large amount of deposits are deposited, etc.
In addition, the preparation process of the bare copper structure IUD is complicated: first, polyethylene and other materials are prepared into a T-shaped bracket, and then copper wires are wound or copper sleeves are embedded on the longitudinal arm of the bracket and the cross arms on both sides; For the bare copper structure IUD containing copper, on the basis of the IUD containing steroid hormones, the copper wire or the copper sleeve should be embedded on the cross arms on both sides of the stent

Method used

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  • Active endouterine contraceptive device made of composite material
  • Active endouterine contraceptive device made of composite material

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Weigh 5 g of megestrol and 15 g of medical-grade low-density polyethylene (LDPE), and prepare a gamma-shaped composite material active IUD by premixing, blending, pressure injection or injection molding.

[0026] Examples 2-18 were all prepared by a method similar to that of Example 1, and the components of the prepared composite active IUD are shown in Table 1.

[0027] Reality

[0028] The technical effect of using low-density polyethylene as the base material is obviously better than that of using silicone rubber as the base material, so the preferred base material is low-density polyethylene. Steroidal hormonal contraceptives can use the various progestogens available. Since the melting points of megestrol, norethindrone and levonorgestrel, etc. are higher than the thermal processing temperature of the active IUD of the composite material, the steroid hormone contraceptives preferably used are megestrol, methyl acetylene, etc. nordrone and levonorgestrel...

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Abstract

An active intra-uterine device (IUD) is prepared from the basic material (low-density polyethene or silicon rubber) and the active substance chosen from steroid hormone contraceptive, Cu particles and copper oxide particles through proportional mixing and blow moulding.

Description

technical field [0001] The invention relates to a female contraceptive device, in particular to a composite material active intrauterine device, which is loaded with steroid hormone contraceptives, copper particles or copper oxide particles alone or in combination. technical background [0002] China is a country with a large population. The huge population base and the annual population growth of 13 million have become important reasons for restricting China's economic and social development, affecting the quality of life of the people and improving the quality of the population. For quite a long time, controlling population growth is still the focus of family planning work. While striving to develop the economy and productivity, it is necessary to implement the basic national policy of family planning more effectively. Therefore, the development of long-acting, safe contraceptives has very important significance in my country. [0003] Intrauterine device (IUD) is a kind ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F6/14A61K31/57A61K33/34A61P15/18
Inventor 谢长生夏先平朱长虹蔡水洲
Owner HUAZHONG UNIV OF SCI & TECH
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