Propofol-containing fat emulsion preparation

Abstract

The present invention provides a propofol-containing fat emulsion that can be administered with reduced vascular pain without incorporating a local anesthetic such as lidocaine; and a process for producing the same. The fat emulsion comprises 0.1 to 5 w / v% of propofol, 2 to 20 w / v% of an oily component, 0.4 to 10 w / v% of an emulsifier and 0.02 to 0.3 w / v% of at least one compound selected from the group consisting of cyclodextrins, cyclodextrin derivatives and pharmacologically acceptable salts thereof, and is in the form of a fat emulsion.

Description

technical field [0001] The present invention relates to fat emulsions containing propofol (PROPOFOL), the administration of which reduces vascular pain. Background technique [0002] Propofol (2,6-diisopropylphenol) is a lipophilic substance that induces hypnosis. Due to its poor water solubility, propofol is usually prepared as an oil-in-water fat emulsion using oily components and emulsifiers, which can be administered directly into the bloodstream by intravenous injection or infusion. Such a fat emulsion containing propofol is widely used as a general anesthetic, a sedative, etc. (see, for example, U.S. Patent No. 5,714,520). Its known commercially available products include, for example, 1% Diprivan TM injection (AstraZeneca). [0003] However, it has been reported that during the administration of such preparations by intravenous injection or infusion, side effects of severe pain (vascular pain) generally occur (see, for example, W. Klemment, J.O. Arndt, British Jour...

AI Technical Summary

Problems solved by technology

[0008] Therefore, a propofol-containing fat emulsion that prevents or relieves the occurrence of severe pain, etc. during administration without compromising the stability and safety of the emulsion has not yet been developed.

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