Enantiomerically pure atomoxetine and tomoxetine mandelate

A technology of atomoxetine hydrochloride and atomoxetine is applied in the field of enantiomerically pure atomoxetine and atomoxetine mandelate, which can solve the problem of contamination, difficulty in implementation, time-consuming, etc. question
CN1946677AInactive Publication Date: 2007-04-11TEVA PHARMA FINE CHEMI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TEVA PHARMA FINE CHEMI
Publication Date
2007-04-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides enantiomerically pure (R)-(-)-tomoxetine (S)-(+)-mandelate and atomoxetine HCI. The present invention further provides enantiomerically pure (R)-(-)-tomoxetine (S)-(+)-mandelate prepared from racemic 5 tomoxetine. The present invention also provides enantiomerically pure atomoxetine HCI prepared from (R)-(-)-tomoxetine (S)-(+)-mandelate.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of the following U.S. Provisional Patent Applications: No. 60 / 583,641, filed June 28, 2004; No. 60 / 609,716, filed September 14, 2004; No. 60 / 622,065; October 25, 2004 No. 60 / 652,330, filed February 11, 2005; No. 60 / 583,644, filed June 28, 2004; No. 60 / 652,332, filed February 11, 2005; No. 60 / 583,643 , filed June 28, 2004; No. 60 / 652,331, filed February 11, 2005; No. 60 / 666,666, filed March 30, 2005; No. 60 / 675,369, filed April 26, 2005 ; Application No. not yet available (Attorney's Abstract No. 12670 / 46803), filed June 9, 2005; and Application No. not yet available (Attorney's Abstract No. 12670 / 47001), filed June 14, 2005; all of these applications The contents are listed as references in this paper. technical field

[0003] The present invention relates to enantiomerically pure atomoxetine and tomoxetine mandelate obtained after optical resolution of racemic atomoxetine. Backgro...

Claims

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