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Synthetic protein as tumor-specific vaccine

A protein and tumor technology, applied in the medical field, can solve problems such as limiting immunological effects

Inactive Publication Date: 2007-04-18
LEIDEN UNIV (MEDICAL CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, on the other hand, the length limitation of chemically synthesized peptides also limits their immunological effects as vaccines

Method used

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  • Synthetic protein as tumor-specific vaccine
  • Synthetic protein as tumor-specific vaccine
  • Synthetic protein as tumor-specific vaccine

Examples

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Embodiment Construction

[0017] Accordingly, a first aspect of the invention relates to a method for producing a synthetic protein. The synthetic protein preferably comprises an amino acid sequence that is at least 80, 85, 90, 95, 97, 98, 99 or 100% identical to at least 46 contiguous amino acids of a naturally occurring antigenic protein of a pathogen or tumor. The method of the present invention comprises the following steps: (a) chemically synthesizing two or more fragments, each fragment is composed of 2-80 consecutive amino acids in the amino acid sequence, wherein in the amino acid sequence, the two or two or more fragments are adjacent and non-overlapping; (b) chemically link the C-terminus of one fragment to the N-terminus of an adjacent fragment to produce a synthetic protein or a portion thereof; (c) optionally, repeat step C to sequentially Further adjacent fragments obtained from step C or step B are ligated to produce the synthetic protein.

[0018] Preferably, the synthetic protein comp...

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Abstract

The invention provides a GMP compatible method to chemically synthesize proteins which may be advantageously used in compositions for vaccination that are free of biological contaminants. The method uses conventional synthesis of peptides and linking these to yield synthetic proteins that preferably comprise all T cell epitopes for an antigen. Preferably an adjuvant is covalently attached to a synthetic protein to yield a fully synthetic vaccine. The invention is illustrated mainly by using HPV proteins directed immunity as a model.

Description

technical field [0001] The present invention relates generally to the field of medicine, and more particularly to inducing and / or enhancing a T cell response to an antigen by utilizing synthetic peptides and linking these synthetic peptides to generate a synthesis comprising all T cell epitopes of the antigen protein is achieved. Preferably, the adjuvant is covalently linked to the synthetic protein to create a synthetic vaccine. The invention is primarily exemplified by using HPV directed immunity as a model. However, the present invention should not be construed as being limited to HPV, but rather having relevance to a wide variety of immune-related diseases or diseases that may be immune-related. Background technique [0002] HPV infection is highly prevalent among young, sexually active male and female individuals. Large prospective studies have shown that HPV infection from male partners is common, occurring in 40-60% of subjects during a 3-year follow-up period (Kou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00C07K14/00C07K14/025A61K38/00
CPCA61K2039/55561C12N2710/20022A61K38/00C12N7/00A61K39/00C07K14/005A61P31/00A61P35/00
Inventor 舒尔德·亨里克斯·范德伯格扬·沃特·德里杰夫豪特
Owner LEIDEN UNIV (MEDICAL CENT)
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