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Quick-slow compound medicine of anti-tuberculosis

An anti-tuberculosis and drug technology, applied in the direction of antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effect of fast onset time and long residence time in the body

Inactive Publication Date: 2007-05-02
江西万基药物研究院药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most anti-tuberculosis drugs at home and abroad are common preparations, and there is no research report on making the anti-tuberculosis compound rifampicin (rifampicin + isoniazid) into a "fast-slow double-release" preparation

Method used

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  • Quick-slow compound medicine of anti-tuberculosis
  • Quick-slow compound medicine of anti-tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Rifampicin 2 servings

[0048] Isoniazid 1 part

[0049] Crospovidone 0.14 parts

[0050] Hydroxypropyl methylcellulose 0.5 parts

[0051] According to the pharmacologically acceptable preparation method, the tablet is made.

Embodiment 2

[0053]Rifampin 2 servings

[0054] Isoniazid 1 part

[0055] 0.14 parts of sodium carboxymethyl starch

[0056] Hydroxypropyl methylcellulose 0.7 parts

[0057] According to the pharmacologically acceptable preparation method, a dry suspension is prepared.

Embodiment 3

[0059] Rifampin 2 servings

[0060] Isoniazid 1 part

[0061] Sodium Croscarmellose 0.13 parts

[0062] 0.52 parts of hydroxypropyl methylcellulose

[0063] According to a pharmacologically acceptable preparation method, a capsule is prepared.

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Abstract

A both fast-release and slow-release compound medicine for preventing and treating tuberculosis (TB) is prepared from rifampin, isoniazid in the ratio of 2:1, and the pharmacologically acceptable auxiliary consisting of skeleton material and disintegrant. Its preparing process is also disclosed.

Description

Technical field [0001] The invention relates to a new anti-tuberculosis fast-slow-release compound drug, in particular to a fast-slow double-release preparation of the anti-tuberculosis compound rifampicin (isoniazid + rifampin). Background technique [0002] Currently, among global infectious diseases, tuberculosis has become the number one killer and the biggest cause of death. Regarding the fact that the tuberculosis epidemic is getting worse, the WHO declared to the world in 1993 that the world is in a state of tuberculosis emergency; March 24 every year is designated as World Tuberculosis Day; my country’s Ministry of Health also listed the original as a Class C infection in 1996 Tuberculosis under disease management has risen to category B management. At present, tuberculosis is re-epidemic and shows an increasingly serious trend. Generally speaking, there are several reasons: 1. The neglect of tuberculosis in various countries in the past 20 years and the relatively backwa...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/4409A61P31/06
Inventor 余华陈新菊曾文丽郭晟肖小华利家平方铝朱令元
Owner 江西万基药物研究院药业有限责任公司
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