Triple high immunity immunoglobulin for anti swine pest, aujeszkys disease of pig, and parvovirus of pig

A technique for porcine pseudorabies and immunoglobulin, which is applied in the fields of porcine pseudorabies, porcine parvovirus immunoglobulin, and anti-swine fever, can solve the problems of high cost of feeding, serious economic losses, and no piglets, and achieves a short course of treatment, Short half-life, good clinical application effect

Inactive Publication Date: 2007-05-09
张中洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

severe economic loss
[0010] On the other hand, for the treatment of viral diseases, there is no specific drug for antiviral diseases like antibiotics that are very specific for bacteria. After the animal becomes ill, antibiotics or immunomodulatory agents are used only to control the concurrent bacterial infection. Infecting and improving the non-specific immune function of the animal body cannot fundamentally solve the problem
Moreover, after the onset of the disease in the herd, it has already caused the abortion of sows and the death of piglets. At this time, it is too late to treat with drugs, because the cost of feeding has been spent during the pregnancy of sows, and the expected piglets have not been obtained. At the same time, some sows had to be culled

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The immunogen used in the present invention is prepared by adding complete Freund's adjuvant after concentrating the cell culture, wherein the swine fever virus is cultured with bovine testicular primary cells or PHK-21 passage cells, and the porcine pseudorabies virus is cultured with porcine kidney cells (PK-15) or bovine kidney cells (MDBK) were cultivated, porcine parvovirus was cultured with porcine kidney primary or secondary cells; after concentration, the titer of these three viruses reached 10 6～8 , the three immunogens were mixed in a volume ratio of 1:2:1.5, and then Freund's adjuvant was added in a volume ratio of 1:1 as an immunogen to immunize animals. At the same time, the glycoside injection developed by Jilin Jingxiang Animal Pharmaceutical Co., Ltd. was used as an immune enhancer, 5 ml / bottle, to increase the antibody titer.

[0045] Preparation method of the present invention:

[0046] Immunization program

[0047] The immunized animals of the prese...

Embodiment 2

[0061]The swine fever virus is cultured with bovine testis primary cells or PHK-21 subcultured cells, the porcine pseudorabies virus is cultured with porcine kidney cells (PK-15) or bovine kidney cells (MDBK), and the porcine parvovirus is cultured with porcine kidney primary or subcultured cells. Generation cell culture; the titers of these three viruses reached 10 after concentration 6～8 , the three immunogens were mixed in a volume ratio of 1.5:1:1.5, and then Freund's adjuvant was added in a volume ratio of 1:1 as an immunogen to immunize animals. At the same time, the glycoside injection developed by Jilin Jingxiang Animal Pharmaceutical Co., Ltd. was used as an immune enhancer, 5 ml / bottle, to increase the antibody titer.

[0062] The preparation method is the same as in Example 1.

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Abstract

An immunoglobulin for preventing the cholera, pseudorabies and parvovirus of hog is prepared from their immunogens through proportional mixing them together and proportionally mixing it with complete Frennd's adjuvant. It features that the glycoside-peptide injection is used as its immunopotentiator.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to an immunoglobulin against swine fever, porcine pseudorabies and porcine parvovirus prepared by using three immunogens. The international patent classification number is A61K39 / 395. Background technique [0002] Classical swine fever (CSF, Hog chorea HC) is a devastating infectious disease of pigs, also known as hog cholera in the early years, is a severe infectious disease caused by swine fever virus. Since it was first reported in Tennessee, USA in 1810, it has become a global epidemic. In recent years, except for North America, Oceania and a few countries in Europe, it is still the biggest threat to the pig industry and the most important infectious disease of pigs at present. The International Health Regulations of the International Office of Epizootics (OIE) classifies swine fever as one of the 16 severe infectious diseases of Class A research; when it passes through ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/295A61K39/39A61K39/395A61P31/12
Inventor 张中洋
Owner 张中洋
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