Duodenum targeted orally administered pharmaceutical formulation, preparation method and application thereof
A drug preparation and duodenal technology, which is applied in the field of duodenum-targeted oral drug preparations, can solve the problems of difficult cure, poor treatment effect, and shortened treatment time, and achieve the promotion of ulcer healing, low price, and inhibition of ulcer healing. The effect of gastric acid secretion
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Embodiment 1
[0022] Dissolve HPMC in glacial acetic acid, and control the temperature at 85-90°C to completely dissolve it. Then add maleic anhydride, acetic anhydride and anhydrous sodium acetate, control the temperature at 85-90° C. for 5 hours, and terminate the reaction with purified water. Add concentrated hydrochloric acid to the reaction solution, shake it well, then slowly pour it into excess purified water while stirring mechanically to obtain a white flocculent polymer. Filter under normal pressure, and wash the product with purified water until neutral. Vacuum-dry at 50°C and pulverize to obtain HPMCAM. The sensitive pH is 3.2-3.4.
[0023] Add water to decoct the clean Coptidis Rhizoma and Evodia rutaecarpa in a prescription amount of 6~1:1~6(w / w) twice, mix the decoction, purify with ion exchange resin, concentrate and dry to obtain the active ingredients, add appropriate amount of starch and carboxymethyl Sodium starch starch, mix evenly, make soft material with an appropri...
Embodiment 2
[0025] The preparation method of HPMCAM is the same as above, and HPMCAM with a sensitive pH of 2.5-3.2 is prepared by adjusting the feeding amount of maleic anhydride and acetic anhydride.
[0026] The preparation method of active component is the same as embodiment 1, gets active component, hydroxypropyl methylcellulose (HPMC K4M), carbomer, lactose, fully grinds, mixes evenly, and 15% PVP ethanol solution is binder and makes soft Material, extrusion granulation, tablet compression, coated aluminum-plastic blister packaging.
Embodiment 3
[0028]The preparation method of the HPMCT is the same as above, and the HPMCT with a sensitive pH of 3.6-3.8 is prepared by adjusting the feeding amount of the trimellitic anhydride.
[0029] The preparation method of active component is the same as embodiment 1, in chitosan or its derivative and active component solution, add tripolyphosphate (TPP) anion, utilize the free amino group of chitosan and TPP anion to generate intermolecular or intramolecular interaction Combined reaction to prepare chitosan microspheres (0.01-250um), coat with HPMCT organic solution, determine the subpackage amount according to the main drug content of the coated microspheres, pack into capsules, and subpackage in aluminum-plastic blisters.
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