Duodenum targeted orally administered pharmaceutical formulation, preparation method and application thereof

A drug preparation and duodenal technology, which is applied in the field of duodenum-targeted oral drug preparations, can solve the problems of difficult cure, poor treatment effect, and shortened treatment time, and achieve the promotion of ulcer healing, low price, and inhibition of ulcer healing. The effect of gastric acid secretion

Inactive Publication Date: 2007-05-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose is to alleviate or eliminate symptoms, promote ulcer healing, and reduce complications; but because it is difficult to directly or mainly reach the lesion in drug treatment and treat the disease direct

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve HPMC in glacial acetic acid, and control the temperature at 85-90°C to completely dissolve it. Then add maleic anhydride, acetic anhydride and anhydrous sodium acetate, control the temperature at 85-90° C. for 5 hours, and terminate the reaction with purified water. Add concentrated hydrochloric acid to the reaction solution, shake it well, then slowly pour it into excess purified water while stirring mechanically to obtain a white flocculent polymer. Filter under normal pressure, and wash the product with purified water until neutral. Vacuum-dry at 50°C and pulverize to obtain HPMCAM. The sensitive pH is 3.2-3.4.

[0023] Add water to decoct the clean Coptidis Rhizoma and Evodia rutaecarpa in a prescription amount of 6~1:1~6(w / w) twice, mix the decoction, purify with ion exchange resin, concentrate and dry to obtain the active ingredients, add appropriate amount of starch and carboxymethyl Sodium starch starch, mix evenly, make soft material with an appropri...

Embodiment 2

[0025] The preparation method of HPMCAM is the same as above, and HPMCAM with a sensitive pH of 2.5-3.2 is prepared by adjusting the feeding amount of maleic anhydride and acetic anhydride.

[0026] The preparation method of active component is the same as embodiment 1, gets active component, hydroxypropyl methylcellulose (HPMC K4M), carbomer, lactose, fully grinds, mixes evenly, and 15% PVP ethanol solution is binder and makes soft Material, extrusion granulation, tablet compression, coated aluminum-plastic blister packaging.

Embodiment 3

[0028]The preparation method of the HPMCT is the same as above, and the HPMCT with a sensitive pH of 3.6-3.8 is prepared by adjusting the feeding amount of the trimellitic anhydride.

[0029] The preparation method of active component is the same as embodiment 1, in chitosan or its derivative and active component solution, add tripolyphosphate (TPP) anion, utilize the free amino group of chitosan and TPP anion to generate intermolecular or intramolecular interaction Combined reaction to prepare chitosan microspheres (0.01-250um), coat with HPMCT organic solution, determine the subpackage amount according to the main drug content of the coated microspheres, pack into capsules, and subpackage in aluminum-plastic blisters.

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Abstract

The invention relates to a duodenum target oral agent, wherein it uses the extractives of 6-1:1-6 coptis root and evodia rutaecarpa as active components, mixed with biological adhesive, stuff, and lubricant, etc; it packs one or multilayer of macromolecule material sensitive with pH on corn as package, while the pH range is 2.5-4.1; the inventive drug can be orally taken to be transmited into duodenum, to quickly release or slowly release. The inventive drug can be made into tablet, drop, etc. And it has low cost and simple production.

Description

technical field [0001] The invention relates to a drug for treating peptic ulcer disease, in particular to a duodenum-targeted oral drug preparation, a production method and a medical application of the preparation. Background technique [0002] Peptic ulcer disease is an ancient chronic digestive system disease, and it is also a global frequently-occurring disease. The formation and development of ulcer disease are related to the digestion of gastric acid and pepsin in gastric juice, so it is named. Huang Wenzhu, Zhang Yali, Zhang Zhenshu and others said in "Modern Enteropathy" published by Military Medical Science Press in March 2003 that the disease has long-term, periodic and rhythmic characteristics, and the treatment effect is not satisfactory, and it is difficult to cure it. Health and normal life and work have had a greater impact. Moreover, many data show that 10% to 20% of people will suffer from peptic ulcer in their lifetime. In recent years, with the accelera...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/16A61K9/36A61K9/52A61K9/50A61P1/04A61P35/00
Inventor 黄园张志荣
Owner SICHUAN UNIV
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