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System and method for transdermal delivery of an anticoagulant

An anticoagulant, transdermal delivery technology, applied in the fields of electrotherapy, blood diseases, drug delivery, etc., can solve the problems of low bioavailability of anticoagulants, increased oral absorption rate, etc.

Inactive Publication Date: 2007-05-30
ALZA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These difficulties are exacerbated by the characteristically low bioavailability and variable oral absorption rates of anticoagulants, including factor Xa inhibitors

Method used

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  • System and method for transdermal delivery of an anticoagulant
  • System and method for transdermal delivery of an anticoagulant
  • System and method for transdermal delivery of an anticoagulant

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Embodiment Construction

[0052] Before the present invention is described in detail, it is to be understood that this invention is not particularly limited to materials, methods or structures illustrated, as such may, of course, vary. Thus, although many materials and methods similar or equivalent to those described herein find use in the present invention, the preferred materials and methods are described herein.

[0053] It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to be limiting of the invention.

[0054] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0055] Additionally, all publications, patents and patent applications cited herein, whether supra or infra, are hereby incorporated by reference in their entirety.

[0056] Finally, as used in this...

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Abstract

A device for transdermally delivering an anticoagulant agent by electrotransport. Preferably, the anticoagulant comprises a benzamidine or a naphthamidine derivative. A particularly preferred benzamidine derivative is a 2-[3-[4-(4-piperidinyloxy) anilino]-1-propenyl]benzamidine derivative. The devices are configured to maintain a plasma concentration of 20-80 ng / mL or providing a flux in the range of approximately 20 - 40 mg / day. Suitable current densities include 0.050 and 0.10 mA / cm<2>. Methods of the invention include delivering the anticoagulants to precisely maintain the desired plasma concentrations. The invention also comprises treating thromboembolic disease and inhibiting Factor Xa.

Description

technical field [0001] The present invention relates generally to electrotransport agent delivery and, more particularly, to transdermal electrotransport agent delivery of anticoagulants. In particular, the present invention relates to methods and systems for obtaining and maintaining appropriate plasma concentrations of anticoagulants, such as benzadamine derivatives, via transdermal delivery. Background technique [0002] Transdermal delivery of bioactive agents or drugs offers improvements over more conventional delivery methods such as subcutaneous injection and oral delivery. Transdermal drug delivery is a particularly attractive route of administration for active agents with narrow therapeutic indices, short half-lives, and potent activity. [0003] Transdermal drug delivery avoids the hepatic first-pass effect and gastrointestinal degradation associated with oral active agent delivery. Transdermal drug delivery also eliminates patient discomfort, infection risk, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61K31/455A61N1/30A61K9/00A61K9/70A61P7/02A61N1/32
CPCA61N1/325A61K9/7023A61K9/0009A61K31/455A61N1/044A61N1/0448A61N1/30A61K31/155A61P7/02A61M37/00
Inventor S·塔克哈R·V·帕德马纳布汉J·B·菲普斯J·A·苏布拉莫尼
Owner ALZA CORP
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