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Medicinal composition with anti-inflammation effect and its preparing method

An anti-inflammatory effect and composition technology, which can be used in drug combinations, medical preparations containing active ingredients, anti-inflammatory agents, etc. Effect

Inactive Publication Date: 2007-06-13
上海慈瑞医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of eye inflammation also requires the use of antibiotics, especially the use of chloramphenicol and tetracyclines, which have relatively large side effects, causing a certain degree of hidden danger to the safety of patients

Method used

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  • Medicinal composition with anti-inflammation effect and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of injection

[0024] Take 3 parts of Prunella vulgaris and 1 part of eucalyptus leaves, combine and pulverize them, put them into a supercritical fluid extraction tank, use carbon dioxide as the supercritical extraction fluid, flow 2.5 liters / min, pressure 25MPa, temperature 35°C, and time 80 minutes to obtain Prunella vulgaris and eucalyptus essential oil extract;

[0025] Take 3 parts of honeysuckle, cut them into small sections about 1 cm long, put them into a volatile oil extractor, add 10 times the amount of water, heat and boil for 5 hours, collect the distillate, add diethyl ether of equal volume to the distillate, Shake evenly, separate the ether layer, evaporate the ether at 45°C to obtain honeysuckle volatile oil;

[0026] Mix the volatile oil extracts of Prunella vulgaris and eucalyptus leaves with the volatile oil of honeysuckle, add water for injection to the prescribed volume, add 9g sodium chloride and 3ml Tween 80 per 1000...

Embodiment 2

[0027] Embodiment 2: Preparation of eye drops

[0028] Take 1 part of Prunella vulgaris and 4 parts of eucalyptus leaves, combine and pulverize them, put them into a supercritical fluid extraction tank, use carbon dioxide as the supercritical extraction fluid, flow 2.5 liters / min, pressure 25MPa, temperature 35°C, and time 80 minutes to obtain Prunella vulgaris and eucalyptus essential oil extract;

[0029] Take 3 parts of honeysuckle, cut into small pieces about 1 cm long, put them into a volatile oil extractor, add 10 times the amount of water, heat and boil for 5 hours, and collect the distillate. Add the same volume of ether as the distillate to the distillate, shake evenly, separate the ether layer, evaporate the ether at 45°C to obtain honeysuckle volatile oil;

[0030] Take the volatile oils of Prunella vulgaris, Eucalyptus leaves and honeysuckle, mix them, add normal saline to the prescribed volume, add 4ml Tween 80 per 1000ml, let stand for 24h, filter; 4 Finely fil...

Embodiment 3

[0031] Embodiment 3: the preparation of eye drops

[0032] Take 5 parts of Prunella vulgaris and 3 parts of Eucalyptus leaves, combine and pulverize them, put them into a volatile oil extractor, add 9 times the amount of water, pass through steam for distillation for 4 hours, collect the initial distillate, and redistill for 3 hours to obtain Prunella vulgaris and Eucalyptus Leaf volatile oil;

[0033] Take 1 portion of honeysuckle, extract twice with 75% ethanol under reflux, add 8 times the amount of ethanol for the first time, reflux for 2 hours, pour out the extract; add 6 times the amount of ethanol for the second time, reflux for 1 hour, combine the extracts, and filter , the filtrate was decompressed to recover ethanol and concentrated, and the pressure was -0.5Mpa to vacuum dry to obtain the honeysuckle extract;

[0034] Take Prunella vulgaris, eucalyptus volatile oil and honeysuckle extract, mix them, add normal saline to the prescribed volume, add 2ml Tween 80 per 1...

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Abstract

The present invention relates to a medicine composition with the function of resisting inflammation. Said medicine composition is formed from (by weight portion) 1-6 portions of prunella spike, 1-5 portions of eucalyptus leaf and 1-4 portions of lonicera flower. Said invention also provides its preparation method and concrete steps. Said medicine composition can be made into injection or eye drops, and can be used for curing the diseases of pelvic inflammation, cervicitis, salpingitis, vulvitis, vaginitis, conjunctivitis, keratitis and trachoma, etc, and can obtain obvious therapeutic effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition with anti-inflammatory effect and a preparation method thereof, which can be used for treating gynecological inflammation and eye inflammation, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Inflammation, especially local inflammation, is the main external manifestation of many infectious diseases. When inflammation occurs, it is often accompanied by symptoms such as pain, redness, and swelling, and brings a lot of pain and trouble to the patient's life. Common local inflammations include gynecological inflammation and eye inflammation. Gynecological inflammation accounts for a large proportion of gynecological diseases, especially cervicitis, pelvic inflammatory disease, salpingitis, vulvitis and vaginitis. The incidence of eye inflammation such as conjunctivitis, keratitis, trachoma, etc. is also higher. At present, large doses of antibiotics a...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/08A61P29/00A61P15/00A61P15/02A61P27/02
Inventor 金幸汤磊王琰付静静王立峰
Owner 上海慈瑞医药科技股份有限公司
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