Composite intravenous injection emulsion of glossy ganoderma spore oil and coix seed oil and method for making same

A technology of ganoderma lucidum spore oil and coix seed oil, which is applied in the field of medicine, can solve the problems of low cure rate, patient pain, and large toxic and side effects, and achieve the effects of simple and easy preparation process, low curative effect and large drug loading capacity

Inactive Publication Date: 2007-07-04
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no good medicine for radical cure. Chemotherapy is usually used for treatment, but the cure rate is not high, and the side effects are relatively large, which brings great pain to patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Weigh 50 grams of ganoderma lucidum spore oil and 50 grams of coix seed oil, mix well, heat in a water bath to 60°C, add 12 grams of soybean lecithin for injection, stir to dissolve, add 0.5 g of tocopherol, stir and mix to obtain an oil phase. Measure 800ml of water for injection, add 22.5g of glycerin, stir to dissolve, and heat to 75°C to obtain an aqueous phase. Mix the oil phase and the water phase at a temperature of 75°C and emulsify with a shear emulsifier for 5 minutes (rotation speed 2600 rpm) to obtain colostrum. Homogenize the colostrum with a high-pressure homogenizer (pressure 10000 psi) three times, and Sodium oxide solution or hydrochloric acid solution adjusts its pH to 7.9, dilutes to 1000ml with water for injection, subpackages, fills with nitrogen, and sterilizes at 115°C for 30 minutes to obtain compound intravenous injection emulsion of ganoderma lucidum spore oil and coix seed oil. The average particle size of the emulsion is 220nm, the pH is 7.70...

Embodiment 2

[0048] Weigh 10 grams of ganoderma lucidum spore oil, 100 grams of coix seed oil, and 0.5 grams of tocopherol, mix them evenly, and heat them in a water bath to 75°C to obtain an oil phase. Add 12 grams of egg yolk phospholipids for injection and 22.5 grams of glycerin into 800 ml of water for injection, stir to dissolve or disperse, and heat to 75° C. to obtain an aqueous phase. Mix the oil phase and the water phase at a temperature of 75°C, emulsify with a shear emulsifier for 3 minutes (1500 rpm) to obtain colostrum, homogenize the colostrum with a high-pressure homogenizer (pressure 5000 psi) three times, and use Sodium hydroxide solution or hydrochloric acid solution adjusts its pH to 7.1, dilutes to 1000ml with water for injection, subpackages, fills with nitrogen, and sterilizes at 115°C for 30 minutes to obtain compound intravenous injection emulsion of ganoderma lucidum spore oil and coix seed oil. The average particle size of the emulsion is 290nm, the pH is 6.80, th...

Embodiment 3

[0050] Weigh 50 grams of ganoderma lucidum spore oil and 150 grams of coix seed oil, mix well, heat in a water bath to 55°C, add 12 grams of soybean lecithin for injection, stir to dissolve, add 1.0 g of tocopherol, stir and mix to obtain an oil phase. Measure 700ml of water for injection, add 22.5g of glycerin, stir to dissolve, and heat to 55°C to obtain an aqueous phase. Mix the oil phase and the water phase at a temperature of 55°C, emulsify with a shear emulsifier for 6 minutes (8000 rpm) to obtain colostrum, emulsify the colostrum three times by extrusion dispersion, and use sodium hydroxide solution or hydrochloric acid Adjust the pH of the solution to 8.0, dilute to 1000 ml with water for injection, subpackage, fill with nitrogen, and sterilize with circulating steam at 120° C. for 15 minutes to obtain a compound intravenous injection emulsion of ganoderma lucidum spore oil and coix seed oil. The average particle size of the emulsion is 238nm, the pH is 7.60, the conte...

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PUM

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Abstract

Disclosed is a composite intravenous injection emulsion of glossy ganoderma spore oil and coix seed oil, which is prepared from glossy ganoderma spore oil, coix seed oil and pharmaceutically acceptable carrier suitable for preparing venous emulsions which can be solvent for injection, emulsifying agent, isotonic conditioning agent, anti-oxidant, pH regulator. The invention also discloses the process for preparing the emulsion.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound intravenous injection emulsion of ganoderma lucidum spore oil and coix seed oil and a preparation method thereof. The intravenous injection emulsion of the invention can be applied to the preparation of drugs for anti-tumor, anti-HIV and anti-hepatitis B virus, and enhancing body immunity. Background technique [0002] Ganoderma lucidum spore oil is an oily substance extracted from the dried fruiting bodies of the polyporaceae fungus Chizhi or Zizhi. Studies have found that the Ganoderma lucidum spore oil contained in the spores of Ganoderma lucidum is the "main force" that exerts anti-tumor, health care and therapeutic effects. Its The average tumor inhibition rate is as high as 91.6%. Ganoderma lucidum spore oil concentrates all the main components of Ganoderma lucidum spores, and is a collection of functional components in Ganoderma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/107A61P35/00A61P31/18A61P31/20A61P1/16
Inventor 陈建明叶正良张广明高保安
Owner TIANJIN TASLY PHARMA CO LTD
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