Water-soluble microneedle spicules and non-aqueous cosmetic composition containing the same

Abstract

Disclosed herein are water-soluble microneedle spicules for scrubs and a non-aqueous cosmetic composition containing the same. More specifically, the present invention relates to water-soluble microneedle spicules for scrubs, which are in the shape of a triangular pyramid or sexangular pyramid and characterized in that at least any one among the interior angles of the pyramid base of the spicules for scrubs is 90 degrees or less; and a non-aqueous cosmetic composition containing the same.10 110, 120, 130: Separation14 mixture: Gene Mixture15 : Test Group: Control Group

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a U.S. national stage filing under 35 U.S.C. § 371 of International Application No. PCT / KR2016 / 013634 filed Nov. 24, 2016 entitled “Water-Soluble Microneedle Spicules and Non-Aqueous Cosmetic Composition Containing the Same,” which claims priority to and benefit of Korean Application No. 10-2015-0165847 filed Nov. 25, 2015, entitled “Water-Soluble Microneedle Spicules and Non-Aqueous Cosmetic Composition Containing the Same,” and claims priority to and benefit of Korean Application No. 10-2016-0157312 filed Nov. 24, 2016, entitled “Water-Soluble Microneedle Spicules and Non-Aqueous Cosmetic Composition Containing the Same.” The contents of each of these applications are hereby incorporated herein by reference in their entireties.TECHNICAL FIELD[0002]The present invention relates to water-soluble microneedle spicules for scrubs and a non-aqueous cosmetic composition containing the same. More specifically, the present in...

AI Technical Summary

Benefits of technology

[0052]Additionally, another object of the present invention is to provide a non-aqueous cosmetic composition which can prevent a phenomenon of the loss of mechanical strength required as a scrub spicule due to the dissolution or swelling of a water-soluble microneedle spicule by a non-aqueous dispersion medium, by preparing microneedle spicules for scrubs, which remove part of the keratin layer of the skin through the mechanical friction with the keratin layer of the skin, using water-soluble materials followed by dispersion the same in the non-aqueous dispersion medium.

[0067]Additionally, the present invention provides an easy method for preparing a microneedle as described above, thereby enabling mass production and commercialization of the microneedles.

Problems solved by technology

However, since the stratum corneum on the outermost part of the skin having a thickness of 10 μm to 60 μm prevents penetration of foreign materials into the body, the skin penetration rate of the active ingredient is very low.

However, since the diameter of a conventional needle is in the range of a few millimeters and its length is in the range of a few centimeters, the injection needle stimulates a large number of nodules present in the skin, thus causing considerable pain.

Additionally, injection needles have a disadvantage in that they are generally available only in hospitals or professional skin care institutions, and thus normal people cannot use them themselves.

WO 02 / 47555 and U.S. Pat. No. 5,487,726, the step of drug application to the skin and the step of forming the micropores in the keratin layer of the skin are performed separately, thus causing inconvenience to users.

Additionally, in a case where the scrubbing agent gets into the eye during its application, there are problems in that the removal of the scrubbing agent is not easy, and the user may feel the presence of foreign materials, and the cornea may be damaged by rubbing the eyes with the hands.

However, these cosmetics are cosmetic compositions for a massage, which are not intended to deliver the skin of an active ingredient but simply contain a large amount of sugar powder for skin scrub purposes.

Additionally, the sugar scrub powder described in KR Patent No. 10-1206985 has disadvantages in that the sugar particles generally have 6 or more surfaces and thus the angles made by each surface are large, and the edges are blunt, making the scrub effect difficult to increase.

However, when the microneedle spicules prepared by the method of FIG. 1 is applied to the skin, there is a problem in that the ratio of protrusions exhibiting an acute angle of 90 degrees or less is lowered, thereby lowering the efficiency of microchannel formation in the keratin layer of the skin.

As in FIG. 3, when the aspect ratio becomes large, there is a problem in that when filling a water-soluble material that forms microneedle spicules into a mold engraved with a polyangular pyramid for the preparation of scrub spicules, air is difficult to escape therefrom and the water-soluble material cannot be completely filled.

Additionally, when the aspect ratio becomes large, the contact area between the negatively-engraved mold and the formed microneedle spicules becomes relatively enlarged and thus it is difficult to separate the microneedle spicules formed from the mold.

For these reasons, when an attempt was made to form microneedle spicules in the shape of a sharper polyangular pyramid by increasing the aspect ratio, which is the ratio between a diagonal length of the base of a polyangular pyramid shape and a height from the base to the sharp vertex, there were problems in that defective products where the microneedle was not perfectly formed due to defective filling or the molding process was delayed due to difficulty in mold release.

However, the stability of physiological activity of polypeptides, oligopeptides, cell culture filtrates, DNA fragments, RNA fragments, and water-soluble antioxidants are influenced by the surrounding physical or chemical environment, and in particular, when water is present, they easily undergo hydrolysis or denaturation, it is not easy to stably maintain the physiological activity when these materials are added to a cosmetic composition.

Freeze-drying techniques can be applied to raw materials, but it is not easy to apply these techniques to general formulations for finished cosmetic products.

The liposome method can provide a stabilizing effect to some extent, but the method has a problem in that it is difficult to maintain the stability for 6 months or longer.

Therefore, it is well known that the material is difficult to formulate for commercialization which requires a shelf-life period.

However, even using these conventional techniques, it is not easy to maintain the activity of oligopeptide epithelial growth factor (EGF) in cosmetics at room temperature circulation conditions, non-sterile conditions, and aqueous conditions.

In particular, since epidermal growth factor (EGF) is added to cosmetics at a concentration lower than 10 ppm, which is a level allowed to cosmetics, it is almost impossible to maintain the physiological activity of epithelial growth factor (EGF) during the period of storage, distribution, and use.

Due to high molecular weight, oligopeptides, polypeptides, DNA fragments, and RNA fragments cannot penetrate into the skin even when are added to cosmetics and thus they can hardly have effects.

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