Wound healing composition and method for use thereof

a wound healing and composition technology, applied in the field of wound healing compositions, can solve the problems of significant increase in the width of newly synthesized connective tissue and epidermal layers, significant increase in the rate of protein and dna synthesis, and the absence of growth factors in the fluid factors isolated from chronic wounds, etc., to achieve the effect of effective treatment, increasing the local activity of the body's wound healing process, and low cos

Inactive Publication Date: 2005-05-19
DAWSON MONICA E
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016] In accordance with the present invention, it has now been discovered that wounds may be effectively treated with the growth factors that are contained in egg whites of hens. Specifically, topically administered growth factors in pharmacologically effective amounts are useful for increasing the local activity of the body's wound healing process. Accordingly, the present invention is a low cost, over-the-counter, composition containing growth factors isolated from a naturally occurring source—egg whites. The composition may be used to treat any disease state where growth factors play a role including diabetic ulcers, nonhealing wounds, burns, osteomyelitis, trauma wounds, subcutaneous trauma and various forms of dermatitis.
[0020] It is another object of the present invention to treat wounds with a topical agent that is easily administered, economical and well-tolerated by patients.

Problems solved by technology

Studies have shown that fluid factors isolated from chronic wounds lack the presence of growth factors.
In contrast, the addition of partially purified PDGF results in significant dose-dependent increases in the width of the newly synthesized connective tissue and epidermal layers.
Further, the addition of partially purified PDGF results in significant increases in the rate of protein and DNA synthesis and the total content of these components in biopsies taken from the wound site.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0050] In March 1998 a female patient who underwent laminectomy and fusion of T3 and T4 began applying the inventive composition to the surgical wound. This patient experienced no scaring from the surgical wounds and continued to be without scars 10 months post surgery. This patient had a previous history of radical surgery in May 1960 for removal of a right breast tumor. The wound from that surgery healed in approximately one month, but left a large scar. Eighteen months after the May 1960 surgery she had major abdominal surgery, and in 1985 had reconstructive of the right and left breast, but with both surgeries experienced significant scaring. Thus, with the recent surgery, the inventive composition prevented scaring.

example 2

[0051] The wound healing characteristics of the inventive composition was demonstrated on Sprague-Dawley rats using a cream according to Formula 1 applied to a wound once daily for five days per week. The percentage of wound acceleration in days and in size was compared to control. The percent of wound acceleration in days was determined to be 5.19, and the percent of acceleration in size was determined to be 22.07.

[0052] Note: Perccntage wound acceleration in days=(1−TD / CD)×100%, where TD and CD are the days required for 80% wound healing in the treatment and control animals, respectively. Percent wound acceleration in size=(1−TA / CA)×100%, where TA and CA are the areas of the wounds in the treatment in control animals, when 80% wound healing is reached on the former.

example 3

[0053] A male patient routinely plagued by muscle and joint soreness and stiffness related to sports activities on the morning following such activities, applied the inventive composition to the affected areas and found that he experienced no joint soreness the mornings following the sports activities.

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Abstract

A method for reducing or preventing the formation of scar tissue is disclosed. The method comprises applying a pharmacologically effective amount of a composition comprising about 5.0% by weight of ovalbumin, about 1.0% phenoxyethanol, about 0.5% carbomer, and about 0.3% triethanolamine. A method for stimulating fibroblast production is also disclosed. The method comprises applying a pharmacologically effective amount of a composition comprising about 5.0% by weight of ovalbumin, about 1.0% phenoxyethanol, about 0.5% carbomer, and about 0.3% triethanolamine.

Description

FIELD OF THE INVENTION [0001] This invention pertains to wound healing compositions and, particularly, to such a composition comprising of a growth hormone and growth factor in a balanced mixture that will deliver the maximum therapeutic results with non-healing wounds, burns, trauma, and certain dermatological disorders. BACKGROUND OF THE INVENTION [0002] 1. Overview of the Invention [0003] There have been recent dramatic strides with the discovery of growth factors as wound healing agents. Indeed, the discovery of growth factors has triggered great optimism into the possibility of mastering the art of wound healing and intense effort has been launched on the part of medical researchers and pharmaceutical companies to procure, characterize, and harvest these healing enhancement agents. Because it is believed that administering growth factors to patients with dermal and subdermal wounds enhances the speed by which wounds heal, as discussed in greater detail below, it is the object o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/64A61K9/00A61K38/18A61K38/38A61K47/32A61Q7/00
CPCA61K8/64A61K9/0014A61K38/1841A61K38/1825A61K38/1808A61Q7/00A61K47/32A61K38/38A61K2300/00
Inventor DAWSON, MONICA E.
Owner DAWSON MONICA E
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