Use of creatine or creatine compounds for skin preservation
Inactive Publication Date: 2005-08-25
AVICENA GROUP
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[0006] The present invention relates to methods for protecting skin tissue against age related damage or insults such as harmful UV radiation, stress and fatigue by preserving energy pools and protecting against free radical production and oxidative stress. This is achieved by administering an amount of a creatine compound or compounds which modulate one or more of the structural or functional components of the creatine kinase/phosphocreatine system sufficient to prevent, reduce or ameliorate skin damage or skin aging. Compounds which are effective for this purpose include the natural compound creatine in its different hydration or salt forms and analogs of creatine. The compounds can be mixed in with creams, oils, emulsions and the like to be spread readily on skin surfaces. Alternatively, the compounds also can be packaged in a supplement fo
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Mitochondria are the major source of oxygen radicals through the respiratory chain and are also deeply affected by reactive oxygen species (ROS), resulting in serious risks to their
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[0013] The methods of the present invention generally comprise administering to a subject an amount of a creatine compound or compounds. It is thought that the creatine compounds modulate one or more of the structural or functional components of the creatine kinase / phosphocreatine system sufficient to prevent, reduce or ameliorate symptoms of aging and damage to the skin. Components of the system which can be modulated include the enzyme creatine kinase, the substrates creatine and creatine phosphate, and the transporter of creatine. The term “modulate,”“modulation” or “modulating” includes any increase or decrease in the activity of any component of the creatine kinase / phosphocreatine system.
[0014] In one embodiment, the invention pertains to a method for treating a subject (e.g., a mammal, preferably, a human) for skin disorders by administering to the subject an effective amount of a creatine compound such that the skin damage is treated.
[0015] The term “mammal” includes any an...
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Abstract
The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.
Description
RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 09 / 852,966, filed on May 10, 2001, which is a continuation of U.S. Ser. No. 09 / 344,427, filed on Jun. 25, 1999 (now U.S. Pat. No. 6,242,491 B1, issued on Jun. 5, 2001); the entire contents of each of the aforementioned applications are hereby incorporated herein by reference. [0002] Creatine and creatine compounds are discussed in related applications including U.S. patent application Ser. No. 08 / 853,174, filed on May 7, 1997; U.S. patent application Ser. No. 08 / 914,887, filed on Aug. 19, 1997; U.S. patent application Ser. No. 08 / 736,967, filed on Oct. 25, 1996; and U.S. patent application Ser. No. 09 / 285,395, filed on Apr. 2, 1999. The entire contents of each of the applications, including all references cited therein, and hereby expressly incorporated herein by reference.BACKGROUND OF THE INVENTION [0003] The creatine kinase / creatine phosphate energy system is only one component of an elabo...
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