Pharmaceutical solution formulations containing 17-AAG

a technology of pharmaceutical solution and 17-aag, which is applied in the field of pharmaceutical solution formulations, can solve the problems of reducing the sensitivity of proteasome-mediated destruction of aag, discontinuing clinical candidates, and poor water solubility of aag
US20050256097A1Inactive Publication Date: 2005-11-17KOSAN BIOSCI
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KOSAN BIOSCI
Publication Date
2005-11-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

A pharmaceutical solution formulation containing 17-AAG in an amount of up to 15 mg / mL dissolved in a vehicle comprising (i) a first component that is ethanol, in an amount of between about 40 and about 60 volume %; (ii) a second component that is a polyethoxylated castor oil, in an amount of between about 15 to about 50 volume %; and (iii) a third component that is selected from the group consisting of propylene glycol, PEG 300, PEG 400, glycerol, and combinations thereof, in an amount of between about 0 and about 35 volume %.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Application No. 60 / 570,215, filed May 11, 2004, the disclosure of which is incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] This invention relates to pharmaceutical solution formulations containing 17-allylamino-17-demethoxygeldanamycin (“17-AAG”) and methods for their preparation and use.

[0004] 2. Description of Related Art

[0005] Geldanamycin belongs to the ansamycin family of natural products, whose members are characterized by a benzenoid nucleus (typically a benzoquinone or hydroquinone nucleus) connected at two meta positions to form a macrolactam. Besides geldanamycin, the ansamycins include the macbecins, the herbimycins, the TAN-420s, and reblastatin.

[0006] Geldanamycin and its derivatives are the most extensively studied of the ansamycins. Although geldanamycin was originally was identified as a...

Claims

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