Method of delaying ejaculation
a technology of ejaculation and ejaculation, applied in the direction of biocide, sexual disorder, drug composition, etc., can solve the problems of psychological damage to sufferers, inability to enter into or sustain relationships, and impair reproductive success, so as to achieve the effect of delaying ejaculation
Inactive Publication Date: 2006-05-18
AYTU BIOSCI
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
"The patent describes a way to delay ejaculation in men. This is done by giving them a certain medication called tramadol before sexual intercourse. The medication helps to slow down the process of ejaculation."
Problems solved by technology
This dysfunction can lead to an inability to enter into, or sustain, relationships and can cause psychological damage to sufferers.
Premature ejaculation can also impair reproductive success.
All of these treatments have significant drawbacks.
Psychological therapies benefit only a subset of patients and require specialized therapists who may not be available to all patients.
Furthermore, psychological therapies cannot alleviate premature ejaculation resulting from non-psychological causes.
Anesthetic agents decrease sensitivity of tissues, thereby diminishing sexual pleasure.
Also, topical anesthetics can be transferred to sexual partners and thereby decrease their sensitivity and pleasure as well.
With regard to devices, these can be awkward, inconvenient and embarrassing to use.
Additionally, devices can cause irritation to one or both partners.
However, these antidepressants may not be effective for all patients, and their side effects can halt treatment or impair patient compliance.
Disease states or adverse interactions with other drugs may contraindicate the use of these compounds or require lower dosages that may not be effective to delay the onset of ejaculation.
Unfortunately, these compounds have side effects which may contraindicate their use (e.g., ergot alkaloids and D-lysergic acid diethylamide) or have limited effectiveness (e.g., metoclopramide and the like; see PCT application WO 95 / 13072).
Method used
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Experimental program
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Effect test
example 1
Tramadol Hydrochloride Delays Ejaculation
[0054] A tramadol material at doses of 10 mg and higher, taken approximately 30-60 minutes prior to sexual intercourse by the male partner delays ejaculation significantly. It was observed, for example, that a dose of 25 mg tramadol hydrochloride (one-half of a 50 mg ULTRAM tablet, Ortho-McNeil Pharmaceutical, Inc., Raritan, N.J.) taken orally 30-60 minutes prior to sexual intercourse delayed ejaculation by a normal male subject by at least 10-15 minutes. At doses of 50-100 mg, a similar effect was observed. However, it was associated with drowsiness, lightheadedness, dry mouth and a sense of slight euphoria (opioid effect) and, at 100 mg, sometimes ejaculation / orgasm was not achieved. From these observations, it was concluded that a dose of 10-50 mg of a tramadol material, preferably 15-35 mg, most preferably 25 mg, can delay ejaculation significantly and can be used to treat (prevent or reduce) premature ejaculation.
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Abstract
The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation.
Description
CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims benefit of provisional application 60 / 276,806, filed Mar. 16, 2001, and is a continuation of U.S. patent application Ser. No. 10 / 098,826 filed Mar. 15, 2002, the entire disclosure of which are considered to be part of the disclosure of this application and are hereby incorporated by reference.FIELD OF THE INVENTION [0002] The invention relates to a method of delaying ejaculation. In particular, the invention relates to a method of delaying ejaculation by the administration of a tramadol material. BACKGROUND OF THE INVENTION [0003] Premature ejaculation is a debilitating sexual dysfunction. This dysfunction can lead to an inability to enter into, or sustain, relationships and can cause psychological damage to sufferers. Premature ejaculation can also impair reproductive success. [0004] Treatments for premature ejaculation include psychological therapies, topical anesthetics, and the use of devices. All of these tr...
Claims
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IPC IPC(8): A61K31/135A61K31/137A61P15/08
CPCA61K31/137A61P15/00A61P15/08
Inventor BAR-OR, DAVID
Owner AYTU BIOSCI