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Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof

Inactive Publication Date: 2010-05-13
NORDIC NATURALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020]In accordance with the present invention there is further provided a method of reducing serum cholesterol, triglycerides or both in a subject comprising administering to the subject a dosage comprising the above-recited therapeutic compositions.

Problems solved by technology

The aqueous insolubility of lovastatin leads to inadequate dissolution in gastrointestinal fluids and, hence, poor absorption, distribution, and targeted organ delivery.

Method used

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Examples

Experimental program
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Effect test

examples

[0076]In one embodiment a daily dosage is taken to reduce cholesterol and triglycerides, the dosage comprising 1.2 grams per day of Red Yeast Rice extract and 1700 mg of Nordic Naturals® ProOmega® fish oil supplement (which contains 70% Omega-3 oils which are 85.9% EPA and DHA, so that 1700 mg will supply 1000 mg / day of EPA and DHA). Here the weight ratio of fish oil to Red Yeast Rice extract is 1700 / 1200 (1.4:1). To make the mixture add 1200 weights of Red Yeast Rice extract to 1700 weights of fish oil. Add 58 weights (2%) of 70% silica bamboo and 87 weights (3%) of lysine and mix thoroughly to make a stable suspension. Fill gelatin capsules with the mixture such that an integral number of capsules dispenses 3045 grams of the mixture.

[0077]In some embodiments, a daily dose is taken, the dose comprising 1.2 grams per day of Red Yeast Rice extract and 3400 mg of fish oil such as ProOmega® fish oil supplement. Here the weight ratio of fish oil to Red Yeast Rice extract is 2.8 and will...

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Abstract

Medicaments and therapeutic compositions comprise Red Yeast Rice extract and omega-3 polyunsaturated fatty acids and / or derivatives thereof, e.g., DHA, derivatives of DHA, EPA, derivatives of EPA or mixtures thereof. One source of the fatty acids or derivatives thereof is fish oil. The compositions are useful for lowering cholesterol and / or triglyceride levels in a subject.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application is a continuation-in-part of U.S. patent application Ser. No. 11 / 757,340, filed Jun. 1, 2007, the contents of which is incorporated herein by this reference in its entirety. All publications, patents, patent applications, databases and other references cited in this application, all related applications referenced herein, and all references cited therein are incorporated herein by reference in their entirety as if restated here in full and as if each individual publication, patent, patent application, database or other reference were specifically and individually indicated to be incorporated by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The invention relates to compositions and the use of such compositions in nutritional supplements and medicaments, wherein the compositions are combinations of Red Yeast Rice extract, having hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor activity, wit...

Claims

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Application Information

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IPC IPC(8): A61K9/64A61K36/06A61K31/366
CPCA61K9/4858A61K31/20A61K31/341A61K31/351A61K31/355A61K35/60A61K45/06A61K36/88A61K36/06A61K2300/00A61K31/202A61K31/22A61K31/232A61K31/366A61K36/062A61K36/899A61K2236/19A61P3/06A61P9/00
Inventor OPHEIM, JOAR
Owner NORDIC NATURALS