Antibacterial and antifungal peptides

Inactive Publication Date: 2010-07-22
C3 JIAN LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0050]“Treating” or “treatment” of a condition as used herein may refer to preventing the condition, slowing the onset or rate of development of the condition, reducing the risk of developing the condition, preventing o

Problems solved by technology

However, in recent years, the trend in reducing infectious disease mortality has been threatened by the emergence of

Method used

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  • Antibacterial and antifungal peptides

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Example

Example 1

Synthesis and Screening of Antimicrobial Peptides

[0221]Peptides were synthesized utilizing standard solid-phase synthesis methods (Fmoc or Boc chemistries). In certain embodiments, peptides were synthesized using Fmoc (9-fluorenylmethoxy carbonyl) solid-phase synthesis utilizing single or double coupling cycles at 0.01 to 0.25 mmol scales. Briefly, N-terminal deprotection was conducted in 20% (v / v) piperidine / N-methylpyrrolidone (NMP) for 3 min followed by eight washes with NMP. For the coupling cycle, amino acids were solubilized in 0.45 M N-hydroxybenzotriazole (HOBt) / HBTU (O-benzotriazole-N,N,N,N-tetramethyl-uronium hexafluoro-phosphate) in dimethylformamide (DMF) with 0.9 M diisopropyl ethylamine (DIEA) (1:1:1:2 ratio Fmoc amino acid:HOB:HBTU:DIEA) before being added to the resin for 30 min, followed by 10 NMP rinses. As needed, peptides were then labeled N-terminally with 4-molar excess fluorescent dyes or blocking groups in HOBt / HBTU / DIEA coupling solution with shakin...

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Abstract

This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims benefit of and priority to U.S. Ser. No. 61 / 142,830, filed Jan. 6, 2009, U.S. Ser. No. 61 / 151,445, filed Feb. 10, 2009, U.S. Ser. No. 61 / 243,905, filed Sep. 18, 2009, and U.S. Ser. No. 61 / 243,930, filed Sep. 18, 2009, all of which are incorporated herein by reference in their entirety for all purposes.STATEMENT OF GOVERNMENTAL SUPPORT[0002][Not Applicable]FIELD OF THE INVENTION[0003]The present invention relates to the fields of antibiotics and pharmacology. More particularly this invention pertains to the identification of novel antimicrobial peptides (AMPs) that have activity against a number of bacteria and / or fungi.BACKGROUND OF THE INVENTION[0004]The development of antimicrobial agents led to a significant decrease in morbidity and mortality from infectious diseases in this century. This accomplishment was largely due to the widespread use of the major classes of antibiotics, such as the sulfonamides, penicill...

Claims

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Application Information

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IPC IPC(8): A61K38/16C07K14/00C07K7/08C07K7/06A61K38/10A01N37/18A61K38/08C07K16/00A61P31/04A01P1/00
CPCA61K8/64Y02A50/473A61K9/0063A61K9/06A61K38/08A61K38/10A61K38/16A61K41/0009A61K41/0057A61K47/10A61K47/26A61K47/34A61Q11/00A01N37/46C07K7/06C07K7/08C07K14/001A61K41/0071G01N33/569A61K47/6911A61K47/64Y02A50/47A61K9/0019A61K41/10A61P31/00A61P31/04A61P31/10Y02A50/30
Inventor ECKERT, RANDAL H.KAPLAN, CHRISHE, JIANYARBROUGH, DANIEL K.ANDERSON, MAXWELLSIM, JEE-HYUN
Owner C3 JIAN LLC
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