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Use of a container of an inorganic additive containing plastic material

a technology of inorganic additives and containers, applied in the direction of containers, packaging goods, special packaging, etc., to achieve the effect of reducing the physical-chemical interactions of containers

Inactive Publication Date: 2011-09-29
MATTERN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The invention provides a new use for containers made of plastic material containing an additive. These containers can now be used to reduce physical / chemical interactions between the container and the oil, fat, or wax containing formulation inside. This is achieved by adding an inorganic additive to the plastic material, such as titanium dioxide, which prevents the formulation from adsorbing to the container. This new use of containers helps to maintain the stability and effectiveness of the formulation."

Problems solved by technology

However it is known that, due to their character, there are some limitations.

Method used

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Embodiment Construction

[0026]In nasal application forms the suitability of the device for administration is of major importance. This applies to improving patient's compliance by convenient administration. But this also applies to pharmaceutical necessities such as the uniformity of emitted dose and the compatibility of the formulation with the primary packaging material. In pharmaceutical applications it is essential to use inert material for primary packaging; the galenical formulation, the active ingredient and the excipients, should not adversely be influenced by any interaction.

[0027]In principle there are two materials and two types for packaging of nasal formulations: glass vs. plastic and multiple-dose vs. unit-dose containers. The main advantages of plastic materials are their flexibility allowing for a wide range of designs, low weight, shatter resistance, and easy handling. Especially suitable for nasal application are unit-dose containers from plastic because of their small size, because no pu...

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Abstract

The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical / chemical interaction between the container and an oil, fat and / or wax containing formulation contained therein.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the use of a container of an inorganic additive containing plastic material.DESCRIPTION OF THE RELATED ART[0002]Plastic containers are readily used for pharmaceutical preparations. However it is known that, due to their character, there are some limitations. Thus to suppress the reactivity of containers from polyethylene or polypropylene and their copolymers / blends towards certain chemicals several methods are used: plasticizers are avoided which would increase the motility of the chain molecules, polymers of higher density or polyolefin blends (e.g. polypropylene / polyacrylate) are used, the wall thickness is increased or the containers are wrapped (e.g. aluminum foil) or sealed (e.g. fluorination, silicone).[0003]U.S. Pat. No. 4,123,417 (Finberg, 1978) claims that the toughness of LDPE can be increased by a blend comprising low density polyethylene containing an amorphous ethylene-propylene co-polymer having a certain amo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/568A61P5/26
CPCA61J1/14B65D1/0207A61P5/26
Inventor MATTERN, CLAUDIA
Owner MATTERN PHARMA
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