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Compositions of protein receptor tyrosine kinase inhibitors

a technology of tyrosine kinase inhibitors and protein receptors, which is applied in the field of synthetic substituted heterocyclic compounds, can solve the problems of few trka inhibitors, high trka kinase selectivity,

Active Publication Date: 2014-08-14
PURDUE PHARMA LP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides compounds that can inhibit or antagonize the NGF receptor TrkA, which is associated with various diseases such as pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, and dysmyelination or demyelination. The compounds can be used to prepare medications for the treatment and prevention of these diseases. The invention also provides pharmaceutical compositions and methods for treating and preventing these diseases using the compounds described above.

Problems solved by technology

Besides antibodies, however, few TrkA inhibitors are known and very few (if any) show high TrkA kinase selectivity (including staurosporine derived TrkA inhibitors.

Method used

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  • Compositions of protein receptor tyrosine kinase inhibitors
  • Compositions of protein receptor tyrosine kinase inhibitors
  • Compositions of protein receptor tyrosine kinase inhibitors

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Embodiment Construction

[0024]The present invention relates to novel synthetic small molecules that act as inhibitors and / or antagonists of the members of Trk family protein kinases, in particularly the NGF receptor. TrkA.

5.1 Definitions

[0025]Terms used in the claims and specification are defined as set forth below unless otherwise specified.

[0026]The term “a compound of the present invention”, “the compound of the present invention”, “compounds of the present invention”, or “the present compounds” refers to one or more compounds encompassed by the structural formulae and / or any subgeneric formulae disclosed herein and includes any specific compounds within these generic formula whose structure is disclosed herein. Compounds of the invention may contain one or more chiral centers and / or double bonds and therefore, may exist as stereoisomers, such as double-bond isomers (i.e., geometric isomers), the racemic mixtures, enantiomers or diastereomers. Accordingly, the chemical structures depicted herein encompa...

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Abstract

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and / or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application is a Divisional application of U.S. patent application Ser. No. 13 / 133,565, filed Jun. 8, 2011, which is a National Stage Application of International Application No. PCT / US2009 / 067197, filed on Dec. 8, 2009, which claims priority to U.S. Provisional Application No. 61 / 120,827, filed on Dec. 8, 2008, the entire contents of each of which are herein incorporated by reference in their entirety for all purposes.1. FIELD OF THE INVENTION[0002]The present invention relates to synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and / or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorde...

Claims

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Application Information

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IPC IPC(8): C07D261/20A61K31/496A61K45/06
CPCC07D215/20C07D221/06C07D223/32C07D241/44C07D261/20C07D265/36C07D279/16C07D295/13C07D307/77C07D403/14C07D413/12C07D417/12C07D471/04C07D487/04C07D491/04C07D493/06C07D495/04C07D498/04C07D498/06C07D513/04A61K31/496A61K45/06A61K31/404A61K31/4355A61K31/4545A61K31/4709A61K31/495A61K31/498A61K31/4985A61K31/519A61K31/5377A61K31/538A61K31/5383A61K31/5415A61K31/542A61K31/55A61K31/551A61K31/5513A61K31/554C07D215/227C07D221/12C07D221/16C07D223/14C07D223/16C07D281/10C07D403/12C07D491/048A61K31/497A61P1/04A61P3/10A61P7/02A61P9/00A61P9/10A61P11/00A61P13/02A61P13/10A61P17/00A61P17/02A61P17/06A61P19/02A61P21/00A61P21/02A61P23/00A61P25/00A61P25/02A61P25/04A61P25/08A61P25/22A61P25/24A61P25/30A61P25/32A61P25/34A61P29/00A61P31/00A61P31/12A61P31/18A61P35/00A61P35/02A61P35/04A61P37/02A61P37/06A61P39/02A61P43/00C07D407/12C07D413/10C07D207/09
Inventor WU, JAY JIE-QIANGWANG, LING
Owner PURDUE PHARMA LP
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