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Use of akkermansia for treating metabolic disorders

a technology of akkermansia and metabolic disorders, which is applied in the field of treatment of metabolic disorders, can solve the problems that the beneficial effect of direct administration of akkermansia muciniphila has never been described, nor suggested, and achieves the effects of increasing energy expenditure, increasing energy expenditure of said subjects, and increasing energy expenditur

Pending Publication Date: 2015-10-29
UNIVERSITE CATHOLIQUE DE LOUVAIN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes the use of a specific microorganism called Akkermansia muciniphila to treat metabolic disorders such as obesity. The microorganism is thought to improve the balance of microbes in the digestive system, leading to weight loss and better health. The technical effect of the patent is the use of a beneficial microorganism to treat metabolic disorders and improve health.

Problems solved by technology

However, this may be an indirect effect due to the insensitivity of intestinal Akkermansia spp. to the used antibiotic.
Moreover, to the Applicant knowledge, no beneficial effect of the direct administration of Akkermansia muciniphila has never been described, nor suggested.

Method used

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  • Use of akkermansia for treating metabolic disorders
  • Use of akkermansia for treating metabolic disorders
  • Use of akkermansia for treating metabolic disorders

Examples

Experimental program
Comparison scheme
Effect test

examples

[0132]The present invention is further illustrated by the following examples.

Materials and Methods

Mice

[0133]Ob / Ob Experiment:

[0134]ob / ob versus lean study: Six-week-old ob / ob (n=5 / group) mice (C57BL / 6 background, Jackson-Laboratory, Bar Harbor, Me., USA) were housed in a controlled environment (12-h daylight cycle, lights-off at 6-pm) in groups of two or three mice / cage, with free access to food and water. The mice were fed a control diet (A04, Villemoisson-sur-Orge, France) for 16 weeks. Cecal content was harvested immersed in liquid nitrogen, and stored at −80° C., for further Akkermansia muciniphila analysis.

[0135]Ob / Ob Prebiotic Study:

[0136]Six-week-old ob / ob (n=10 / group) mice (C57BL / 6 background, Jackson-Laboratory, Bar Harbor, Me., USA) were housed in a controlled environment (12-h daylight cycle, lights-off at 6-pm) in groups of two mice / cage, with free access to food and water. The mice were fed a control diet (Ob-CT) (A04, Villemoisson-sur-Orge, France) or a control diet su...

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Abstract

The present invention relates to Akkermansia muciniphila or fragments thereof for treating a metabolic disorder in a subject in need thereof. The present invention also relates to a composition, a pharmaceutical composition and a medicament comprising Akkermansia muciniphila or fragments thereof for treating a metabolic disorder. The present invention also relates to the use of Akkermansia muciniphila or fragments thereof for promoting weight loss in a subject in need thereof.

Description

FIELD OF INVENTION[0001]The present invention relates to the treatment of metabolic disorders, such as, for example, metabolic disorders related to overweight and obesity, such as, for example, Diabetes Mellitus or high cholesterol. The present invention more specifically relates to a composition comprising Akkermansia spp or fragments thereof for treating a metabolic disorder.BACKGROUND OF INVENTION[0002]Obesity is a worldwide problem, with an estimated number of obese adults of about 250 million. This epidemic of obesity is correlated with a great increase in the prevalence of obesity-related disorders, such as, for example, Diabetes, hypertension, cardiac pathologies and liver diseases. Due to these highly disabling pathologies, obesity is currently considered in western countries as one of the most important public health problem. There is thus a real need of compositions and methods for treating or preventing obesity and / or obesity-related disorders.[0003]Obesity and obesity-re...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/74A61K9/00A61K35/741A23L2/38
CPCA61K35/74A61K9/0053A61K35/741A61P3/00A61P1/16A61P11/00A61P11/06A61P19/02A61P25/00A61P25/28A61P3/04A61P35/00A61P3/06A61P37/02A61P37/04A61P43/00A61P9/00A61P9/10A61P9/12A61P3/10Y02A50/30A23L33/135A23V2002/00A23V2200/308
Inventor CANI, PATRICEEVERARD, AMANDINEBELZER, CLARADE VOS, WILLEM
Owner UNIVERSITE CATHOLIQUE DE LOUVAIN
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