Anti-cd37 immunoconjugate and Anti-cd20 antibody combinations

an anticd37 and immunoconjugate technology, applied in the field of synergistic combinations of anticd37 immunoconjugate, can solve the problems of relapse or non-repair, poor prognosis of many patients with b cell cancer, etc., and achieve the effects of synergy, efficacy and/or reduction of toxicity
US20170000900A1Inactive Publication Date: 2017-01-05DEBIOPHARM INTERNATIONAL SA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
DEBIOPHARM INTERNATIONAL SA
Publication Date
2017-01-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods of administering immunoconjugates that bind to CD37 (e.g., IMGN529) in combination with antibodies that bind to CD20 are provided. The methods comprise administering an anti-CD37 immunoconjugate (e.g., IMGN529) and an anti-CD20 antibody to a person in need thereof, for example, a cancer patient.
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Description

REFERENCE TO EARLIER FILED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 62 / 263,449, filed Dec. 4, 2015, and U.S. Provisional Application No. 62 / 172,672, filed Jun. 8, 2015, both of which are incorporated herein by reference in their entireties.REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY VIA EFS-WEB

[0002] The content of the electronically submitted sequence listing (Name: 2921_076PC02_SeqListing_ST25.txt, Size: 54,440 bytes; and Date of Creation: Jun. 2, 2016) is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0003] The field of the invention generally relates to synergistic combinations of an anti-CD37 immunoconjugate (e.g., IMGN529) and an anti-CD20 antibody and their use in the treatment of cancer.BACKGROUND OF THE INVENTION

[0004] Cancer is one of the leading causes of death in the developed world, with over one million people diagnosed with cancer and 500,000 deaths per year in the United States alone. O...

Claims

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