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Compositions for Reducing Hair Loss and/or Increasing Hair Regrowth

a technology of hair loss and compositions, applied in the field of compositions for reducing hair loss and/or increasing hair regrowth, can solve the problems of less than 40% effective effect of minoxidil in promoting hair regrowth, and the problem of women's hair loss mostly becoming an issue, so as to reduce hair loss and increase hair regrowth

Inactive Publication Date: 2017-04-13
TRIPLE HAIR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventor has discovered a composition that can be applied to the scalp to reduce hair loss and increase regrowth. This composition contains minoxidil, finasteride, and a prostaglandin analogue. When used together, these components show better results than each one individually. The invention is about a composition containing 2% to 5% minoxidil, 0.01% to 15% finasteride, and 0.01% to 15% of a prostaglandin analogue. This composition is effective in reducing hair loss and promoting hair growth.

Problems solved by technology

Women's hair loss mostly becomes an issue after menopause.
While studies demonstrate the efficiency of 5% minoxidil over the 2% concentration, minoxidil is less than 40% effective in promoting regrowth of the hair.

Method used

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  • Compositions for Reducing Hair Loss and/or Increasing Hair Regrowth
  • Compositions for Reducing Hair Loss and/or Increasing Hair Regrowth
  • Compositions for Reducing Hair Loss and/or Increasing Hair Regrowth

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Composition Comprising Finasteride. Latanoprost and Minoxidil

[0037]In order to prepare the composition, latanoprost was diluted to obtain a concentration of 10,000 mcg / ml of solute on in absolute ethyl alcohol, and prepared as a stock solution and kept in a freezer to enhance stability (−20° C.). Absolute ethyl alcohol was mixed with propylene glycol and heated to 55°-65° C. Minoxidil powder was then added to the alcohol / propylene glycol mixture. In a containment hood, finasteride was added to the solution and stirred until dissolved. The preparation was cooled to room temperature. Ethoxy diglycol and latanoprost were added to the cooled solution and stirred well, until in solution. The final solution was brought to volume with absolute ethyl alcohol.

[0038]The amounts used are set out in Table 1 below:

TABLE 1ComponentFunctionQuantity per unit%Propylene glycolSolvent30ml50Minoxidil USPActive3g5Finasteride USPActive0.06g0.1Ethoxy diglycolSolvent3ml5reagentLatanoprostAct...

example 2

Preparation of Composition Comprising Minoxidil

[0040]A composition comprising 5% minoxidil was prepared. Absolute ethyl alcohol was mixed with propylene glycol and heated to 55° to 65° C. The minoxidil powder was added to the alcohol / propylene glycol mixture. Ethoxy diglycol was added and the solution was stirred. The final solution was brought to volume with absolute ethyl alcohol to obtain a solution comprising 5% minoxidil.

example 3

[0041]Preparation of Composition Comprising Finasteride

[0042]A composition comprising 0.1% finasteride was also prepared. Absolute ethyl alcohol was mixed with propylene glycol. Finasteride was added to the alcohol / propylene glycol mixture to obtain a solution having a concentration of 0.1% finasteride. Absolute ethyl alcohol also serves the function of preservative.

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Abstract

The invention relates to a composition comprising 2% to 5% minoxidil, 0.01% to 15% finasteride and 0.01% to 15% of a prostaglandin analogue. In one embodiment, the prostaglandin analogue is latanoprost. In a preferred embodiment, the composition comprises 5% minoxidil, 0.1% finasteride and 0.03% latanoprost. The invention also relates to the use of the said composition to reduce hair loss and / or increase regrowth of hair in a human subject.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This Non-Provisional Patent Application is a continuation of and claims priority under 35 U.S.C. §120 to U.S. Non-Provisional patent application Ser. No. 14 / 917,501, filed Mar. 8, 2016, which claims priority under 35 U.S.C. §120 and §§119(a)-(d) to and is a national phase patent application of International Patent Application No. PCT / CA2015 / 000327, filed May 22, 2015, entering the U.S. under 35 U.S.C. §371 and Published in English as WO2015 / 176161 A1, which International Application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Patent Application No. 62 / 002,397, filed May 23, 2014 and U.S. Non-Provisional patent application Ser. No. 14 / 917,501, filed Mar. 8, 2016, further claims priority under 35 U.S.C. 119(a)-(d) to Canadian Patent Application No.2,903,734, filed May 22, 2015. The disclosure of each of the above-noted patent applications is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION[0002...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/63A61Q7/00A61K8/04A61K8/49A61K8/37
CPCA61K8/63A61K8/4953A61K2800/592A61K8/046A61Q7/00A61K8/37A61K31/506A61K31/5575A61K31/58A61K9/0014A61K8/361A61P17/14A61K2300/00A61K8/0204
Inventor SEKHAVAT, HOUFAR
Owner TRIPLE HAIR
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