Skin-brightening compositions and methods
a technology of compositions and skin, applied in the field of skin brightening compositions, can solve the problems of ammonia and persulfate based alkaline boosters, strong odors, and general disagreeability of most consumers
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example 1
ith In Vitro Hair and Stratum Corneum Change in Luminosity, Inventive Compositions and Compositions Comprising Ammonia
[0081]Inventive composition is the Inventive Example 1 shown in Table 3, wherein Part A and Part B are combined in equal amounts just prior to application.
[0082]Comparative composition is the Comparative Example 1 shown in Table 4 (includes ammonium bicarbonate as booster).
TABLE 1Lightening efficacy of compositions with and withoutammonia in in vitro hair and stratum corneum test:Comparative Example 1Inventive Example 1PART APART BPART APART BH2O27%7%Guanidine 4%4%BicarbonateAmmonium1.12%Bicarbonateoil50605060Fla 1 = Part A:Part B 1:1Fla 2 = Part A:Part B 1:1pH = 9.0 ± 0.5pH = 9.0 ± 0.5ΔL on hair swatch5.12 ± 0.213.7 ± 0.16ΔL on SC with1.4 ± 0.21.3 ± 0.5 brown background
[0083]In vitro hair swatch test showed that the inventive composition lacking ammonia provides significantly decreased lightening efficacy as compared with the comparative composition, while both inv...
example 2
Stratum Corneum Change in Luminosity, Inventive Compositions with and without Oil and Over Multiple Applications
[0084]Inventive composition is the Inventive Example 1 shown in Table 3 wherein Part A and Part B are combined in equal amounts just prior to application.
[0085]Comparative composition is the Comparative Example 2 shown in Table 4 (without oil).
[0086]In vitro stratum corneum tests were conducted with and without oil, and over one or multiple applications. Table 2 provides the results.
TABLE 2In vitro SC test shows that the efficacy increases with the increased oilcontent and increased number of application:ComparativeExample 2InventiveInventiveInventive(without oil)Example 1Example 1Example 1PART APART BPART APART BPART APART BPART APART BH2O27%7%7%7%Guanidine4%4%4%4%Bicarbonateoil00506050605060Fla 1 = Part A:PartFla 2 = Part A:PartFla 2 = Part A:PartFla 2 = Part A:PartB 1:1B 1:1B 1:1B 1:1pH = 9.0 ± 0.5pH = 9.0± 0.5pH = 9.0 ± 0.5pH = 9.0 ± 0.5# of1123applicationon SCΔL on SC...
example 3
tratum Corneum Change in Luminosity Over Multiple Applications, Comparing Inventive Composition with Hydroquinone Containing Composition
[0088]Inventive composition is the Inventive Example 1 shown in Table 3 wherein Part A and Part B are combined in equal amounts just prior to application.
[0089]Comparative composition comprises hydroquinone.
[0090]In vivo tests were conducted as described above, with application of the compositions being made on the back of test subjects. The inventive compositions were applied twice weekly over four weeks; comparative compositions containing Hydroquinone at 2% were applied five times per week over four weeks, These results in vivo follow the same trend as the in vitro results, demonstrating that an increased change in brightness can be achieved, for example an increase in brightness of ΔL=1.3 after two applications per week for 4 weeks using an inventive composition according to the disclosure as compared with a modest increase in brightness of only...
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