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Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells

a transcription factor and homeobox technology, applied in the field of human biology discoveries, can solve the problems of little knowledge about intrinsic dc factors that can be manipulated to modulate, and the key transcriptional regulatory mechanisms underlying human monocytes to dcs differentiation remain poorly understood

Inactive Publication Date: 2020-07-16
ZHU ZHENGLUN
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

VentX expression is elevated in inflamed mucosa of IBD patients, and its modulation impacts DC maturation responses, providing a potential therapeutic target for inflammatory diseases and immune regulation.

Problems solved by technology

Moreover, aberrant TLR signaling have been found to predispose patients to Crohn's disease.
However, currently, little is known about the intrinsic DC factors that can be manipulated to modulate DC maturation and functions.
Nevertheless, the key transcriptional regulatory mechanisms underlying human monocytes to DCs differentiation remain poorly understood.

Method used

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  • Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells
  • Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells
  • Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells

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Embodiment Construction

[0055]The invention is based, in part, on the discovery that VentX plays an essential role in regulation of DC maturation and function. VentX regulates DCs differentiation and maturation through an IL6 mediated mechanism. VentX expression is elevated in DCs isolated from inflamed mucosa of IBD patients and knockdown of VentX diminished the maturation response of DCs. The data disclosed herein demonstrates that VentX can serve as a target of intervention for inflammatory diseases and immune therapy.

[0056]The disclosure herein establishes that ablation of VentX expression in monocytes significantly impairs their differentiation into DCs. Conversely, overexpression of VentX in monocytic cells THP1 accelerates their differentiation towards DCs. Increased IL6 expression partially accounted for the DCs differentiation defects in monocytes with VentX knockdown. Clinically important is the finding that VentX expression was elevated in intestinal lamina propria DCs (LPDCs) from inflamed muco...

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Abstract

The invention relates to human homeobox transcription factor VentX and its regulation of differentiation and maturation of human dendritic cells, and related therapeutic and diagnostic compositions and methods of use.

Description

PRIORITY CLAIMS AND RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 14 / 781,359, filed on Sep. 30, 2015, which is the U.S. national phase of and claims priority to PCT / US14 / 33577, filed Apr. 10, 2014, which claims the benefit of priority from U.S. Provisional Application Serial No. 61 / 810,610, filed on Apr. 10, 2013, the entire content of each of which is incorporated herein by reference in its entirety.TECHNICAL FIELDS OF THE INVENTION[0002]The invention generally relates to human biology discoveries and therapeutic and diagnostic compositions and methods based thereon. More particularly, the invention relates to human homeobox transcription factor VentX and its regulation of differentiation and maturation of human dendritic cells, and related therapeutic and diagnostic compositions and methods of use.BACKGROUND OF THE INVENTION[0003]Dendritic cells (DCs) are the most potent professional antigen-presenting cells that play critical roles in i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/6883G01N33/68C12N5/0784A61K31/7088A61K38/00A61K31/713A61K38/17C07K16/18C12N15/113G01N33/50G01N33/564
CPCC12Q2600/158C07K2317/76C07K16/18C12N2320/30C12Q1/6883C12N15/113G01N33/686C12N2501/60A61K38/1709A61K38/00G01N33/5023C12Q2600/16G01N2333/47G01N33/564C12N5/0639C12N2310/14A61K31/713A61K31/7088A61P29/00A61P35/00A61P37/00A61P37/06A61P43/00
Inventor ZHU, ZHENGLUN
Owner ZHU ZHENGLUN
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