Antibiotic cannabinoid-terpene formulations

a technology of cannabinoid terpene and formulation, applied in the field of medicinal preparations, can solve the problems of opportunistic infection, increased difficulty in treating enterococcal infections, and known as a leading cause of dangerous infections
US20220218654A1Pending Publication Date: 2022-07-14THE UNIV OF BRITISH COLUMBIA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE UNIV OF BRITISH COLUMBIA
Publication Date
2022-07-14

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Abstract

Pharmaceutical formulations are provided that include at least two antibiotically active ingredients: a cannabinoid that is one or more of cannabichromene (CBC), cannabidiol (CBD) and / or cannabigerol (CBG); a sesquiterpene that is one or both of α-humulene and / or β-caryophyllene; and a lipopeptide antibiotic that is daptomycin or an analogue thereof. The antibiotically active ingredients may be provided in relative amounts that amplify their individual activities, including amounts that are synergistically effective in an assay to inhibit growth and / or reproduction of an Enterococcus faecium or an Enterococcus faecalis. Therapies are provided that utilize these formulations as anti-microbials, and provide for the combined use of two or more of the antibiotically active compounds.
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Description

FIELD OF THE INVENTION

[0001] The invention is in the field of medicinal preparations comprising a mixture of two or more organic antibiotically active ingredients, optionally including specific phenolic cannabinoids in optional combination with specific sesquiterpenes in optional combination with a lipopeptide antibiotic such as daptomycin. The therapeutic use of cannabinoid and / or sesquiterpene formulations is also disclosed, for synergistic treatment of enterococcal infections, including combined uses with lipopeptide antibiotics such as daptomycin.BACKGROUND OF THE INVENTION

[0002] Enterococcus faecium and Enterococcus faecalis are bacterial species that asymptomatically colonize the gastrointestinal (GI) tract in humans, but can also be pathogenic in certain circumstances (in the relevant literature, Enterococcus faecium was previously classified as Streptococcus faecium, see Schleifer & Kilpperbalz, 1984). In particular, these organisms are known to be a leading cause of dangerous...

Claims

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