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Method for preparing ternary aliphatic polyester elastomer capable of biological degradation

A technology of fatty polyester and biodegradation, which is applied in the field of preparation of biodegradable ternary fatty polyester elastomer, can solve the problems of application limitation, difficult degradation, low strength, etc., and achieve low cost, low price and biocompatibility good sex effect

Inactive Publication Date: 2007-09-19
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among the currently used biomedical materials, the preparation of elastin and polyhydroxyalkanoate (PHA) polymers must be fermented by bacteria, which is relatively complicated and limits its application; hydrogels are biocompatible A class of materials with high resistance, but most natural gels have low strength, and the disadvantage of synthetic hydrogels is that they are not easy to degrade

Method used

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  • Method for preparing ternary aliphatic polyester elastomer capable of biological degradation
  • Method for preparing ternary aliphatic polyester elastomer capable of biological degradation
  • Method for preparing ternary aliphatic polyester elastomer capable of biological degradation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 40g of sebacic acid into a three-necked flask, heat it in an oil bath to 160°C under nitrogen protection, and after it is completely melted, slowly add 4.01ml of ethylene glycol dropwise with a constant pressure funnel, react for 3 hours, and lower the temperature to 125°C °C, distilled under reduced pressure for 6 hours to obtain the prepolymer.

[0022] At 150°C, 6.15ml of glycerin was slowly added dropwise to the prepolymer with a constant pressure funnel, reacted for 3 hours, then lowered the temperature to 125°C, and distilled under reduced pressure for 8h to obtain an elastomer. Wash several times with deionized water and ethanol, dry in vacuum and set aside.

Embodiment 2

[0024] Add 40g of adipic acid into a three-necked flask, heat it in an oil bath to 150°C under the condition of nitrogen protection, after it is completely melted, slowly add 4ml of ethylene glycol dropwise with a constant pressure funnel, react for 3 hours, and lower the temperature to 120°C , Distilled under reduced pressure for 6h to obtain the prepolymer.

[0025] At 150°C, 6.15ml of glycerin was slowly added dropwise to the prepolymer with a constant pressure funnel, reacted for 3 hours, then lowered the temperature to 125°C, and distilled under reduced pressure for 6h to obtain an elastomer. Wash several times with deionized water and ethanol, dry in vacuum and set aside.

Embodiment 3

[0027] Add 40g of sebacic acid into a three-necked flask, heat the oil bath to 150°C under the condition of nitrogen protection, and after it is completely melted, slowly add 4.01ml of ethylene glycol dropwise with a constant pressure funnel, react for 3 hours, and lower the temperature to 125°C °C, distilled under reduced pressure for 12 hours to obtain the prepolymer.

[0028] Add 8.5g of pentaerythritol at 150°C, react for 1 hour, lower the temperature to 125°C, and distill under reduced pressure for 6h to end the reaction and obtain an elastomer. Wash several times with deionized water and ethanol, dry in vacuum and set aside.

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Abstract

The present invention discloses one kind of degradable biocompatible ternary aliphatic polyester elastomer. The biodegradable ternary aliphatic polyester elastomer has the preparation process including: the esterification between binary acid and dibasic alcohol to synthesize low molecular weight linear prepolymer, and the esterification crosslinking reaction between the linear prepolymer and polyol to produce the biodegradable ternary aliphatic polyester elastomer. The product has no toxicity, high biocompatibility and low cost, and altering the material proportion can produce various products with different physical properties for different requirements. Compared with other similar material, the aliphatic polyester elastomer has low cost, easy synthesis and excellent biocompatibility.

Description

technical field [0001] The invention relates to the synthesis of polymer materials that can be used in the biomedical field, and more specifically, relates to a preparation method of a biodegradable three-component fatty polyester elastomer. Background technique [0002] Biodegradable polymers are widely used in many fields of bioengineering, such as tissue engineering, drug release and biosensing. Biodegradable elastomers can quickly recover from relatively large deformations, which is beneficial to maintain the transplanted organ's own functions, will not bring mechanical stimulation to the host, and will gradually degrade and disappear with the formation of new tissues, without surgery Taken out, it is an excellent biomedical material. Research and development of biodegradable elastic biomedical materials with good biocompatibility is an important direction for the development of biomaterials. [0003] Among the currently used biomedical mat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/16
Inventor 侯信刘欣宋子峰姚康德
Owner TIANJIN UNIV