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Compound calcium phosphate/Chinese medicine bone alternate material and its preparing method

A replacement material, calcium phosphate technology, applied in the field of medical biomaterials and drugs, can solve the problems of immature research, achieve anti-inflammatory bone healing, promote bone healing, repair and treatment with simple effects

Inactive Publication Date: 2008-01-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on calcium phosphate-based biomaterials as carriers of drugs or different biological signal molecules is still immature, and its effect needs to be further improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0016] Embodiment two: get the tricalcium phosphate that contains the dry matter amount that wet method is synthesized and be 95 grams, adopt diisocyanic acid to carry out surface modification to tricalcium phosphate as surfactant, make uniformly dispersed suspension; Ligustrazine injection with a mass of 5 grams is made into a uniformly dispersed suspension containing Ligusticum chuanxiong. After the tricalcium phosphate precipitate is fully mixed with Ligustrazine injection, the finished product can be obtained by spray drying.

Embodiment 3

[0017] Embodiment 3: Take the mixture of hydroxyapatite and tricalcium phosphate synthesized by wet method, wherein the dry matter content of the mixture containing hydroxyapatite and tricalcium phosphate is 50 grams, and adopt the surfactant of alkyl acid series, p-hydroxyphosphorus The mixture of limestone and tricalcium phosphate is surface-modified to make a uniformly dispersed suspension; add safflower injection containing 50 grams of safflower dry matter to make a uniformly dispersed suspension containing safflower, and the hydroxyl After the mixture precipitation of apatite and tricalcium phosphate is fully mixed with safflower injection, the finished product can be obtained by spray drying.

Embodiment 4

[0018] Example 4: Take the hydroxyapatite synthesized by the wet method with a dry matter content of 75 grams, and use organosilane series surfactants to modify the surface of the hydroxyapatite to make a uniformly dispersed suspension; The Panax notoginseng injection with 25 grams of dry matter is made into a uniformly dispersed suspension containing Panax notoginseng, and after the hydroxyapatite and the Sanqi injection are fully mixed, the finished product can be obtained by spray drying.

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Abstract

The present invention discloses one kind of bone healing-promoting bone-substituting composite calcium phosphate / Chinese medicine material. The composite material consists of calcium phosphate in 50-95 weight portions and Chinese medicine with the functions of promoting blood circulation to disperse blood clots and promoting bone healing in 5-50 weight portions. This kind of bone substituting material may be implanted into bone defecting part to serve as stuffing and rack and may be set in bone defecting part to release medicine for stopping pain, promoting blood circulation to disperse blood clots, diminishing inflammation and promoting bone healing.

Description

Technical field [0001] The invention relates to the fields of medical biomaterials and medicines, in particular to a calcium phosphate / traditional Chinese medicine composite bone replacement material capable of promoting bone healing and a preparation method thereof. Background technique [0002] Bone tissue damage or lesions caused by sports, traffic accidents, or diseases can lead to bone defects; in addition, with the aging of the population, osteoporosis often occurs in the elderly population, which can easily cause fractures or bone defects. The treatment of the above bone defects Both require appropriate bone replacement material for filling replacement. At present, the common bone defect filling materials in clinic include: autologous bone graft, allogeneic bone graft, artificial synthetic materials, etc. Although autologous bone transplantation is the best method, it is limited due to limited bone supply and the need to open up a second surgical field, which brings ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/54A61K36/00A61P19/08
Inventor 屈树新翁杰冯波
Owner SOUTHWEST JIAOTONG UNIV