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A medication composition of acetyl cysteine or a pharmaceutical salt thereof and asarin

A technology of acetylcysteine ​​and its composition, applied in the field of medicine, to achieve wide application prospects, definite curative effect, and the effect of increasing sputum secretion

Inactive Publication Date: 2009-03-04
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, using the interaction between acetylcysteine ​​or its pharmaceutically acceptable salt and asarone, the compatibility formula is used for the treatment of pneumonia, bronchial asthma, chronic obstructive pulmonary disease, and acute inflammation of the lungs. , not yet reported

Method used

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  • A medication composition of acetyl cysteine or a pharmaceutical salt thereof and asarin
  • A medication composition of acetyl cysteine or a pharmaceutical salt thereof and asarin
  • A medication composition of acetyl cysteine or a pharmaceutical salt thereof and asarin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The preparation of embodiment 1 etaminoxine composition powder injection

[0084] 1. Prescription:

[0085] Prescription of etaminoxine composition 1

[0086]

[0087] Prescription of etaminoxine composition 2

[0088]

[0089] 2. Specific steps:

[0090] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0091] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.

[0092] 3) Take sterile water for injection with a dosing volume of 80%, add mannitol and polysorbate 80, heat and stir to dissolve completely, add acetylcysteine ​​and asarone, heat and stir to dissolve completely, add sterile water for injection to Full amount.

[0093] 4) Add activated carbon for needles with a dosing volume of 0.05%, heat and stir for 15 minutes.

[0094] 5) Filtration and decarburization. Measure and adjust the pH of the solution.

[0095] 6) Fine filtration throug...

Embodiment 2

[0100] Example 2 Preparation of Ethaminosarcoma Composition Aqueous Injection

[0101] 1. Prescription:

[0102] Prescription of etaminoxine composition 1

[0103]

[0104] Prescription of etaminoxine composition 2

[0105]

[0106] 2. Specific steps:

[0107] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0108] 2) Take the prescribed amount of ethanol and add an equal amount of water to mix, dissolve asarone, add 40% water for injection and polyethylene glycol 400 to dissolve acetylcysteine, mix the two, add water for injection to Full amount.

[0109] 3) Add activated carbon for needles with a dosing volume of 0.05%, and stir at 40°C for 15 minutes.

[0110] 4) Filtration and decarburization. Measure and adjust the pH of the solution.

[0111] 5) Fine filtration through a 0.45 μm microporous membrane.

[0112] 6) Check the clarity of the solution and test the ...

Embodiment 3

[0117] Example 3 Preparation of Ethaxarin Composition Sodium Chloride Infusion

[0118] 1. Prescription:

[0119] Prescription of etaminoxine composition 1

[0120]

[0121] Prescription of etaminoxine composition 2

[0122]

[0123] 2. Specific steps:

[0124] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use.

[0125] 2) Polysorbate 80 is made into a 20% solution with water for injection, acetylcysteine ​​and asarone are added, heated and stirred to dissolve completely, and sodium chloride is completely dissolved with water for injection with a dosing volume of 40%. Combine the above solutions and add water for injection to the full amount.

[0126] 3) Add activated carbon for needles with a dosing volume of 0.05%, heat and stir for 15 minutes.

[0127] 4) Decarburization by sand filter rod filtration. Measure and adjust the pH of the solution.

[0128] 5) Fine filtration t...

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Abstract

A medical composition used to prepare the medicines for treating pneumonia, bronchial asthma, chronic obstructive pneumonia, and acute inflammation of lung is composed of acetylcysteine or its pharmacologically acceptable salt (20-1200 Wt. portions) and asarone (1-200). Its preparing process is also disclosed.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of acetylcysteine ​​or a pharmaceutically acceptable salt thereof and asarone, a preparation method and application thereof, and belongs to the technical field of medicine. 2. Background technology [0002] In my country's population statistics, respiratory diseases are the second cause of death, mainly including upper respiratory tract infection, acute and chronic bronchitis, pneumonia, etc. The main symptoms are cough, sputum, and asthma. Most are caused by viral infection first, and a few are caused by direct bacterial infection. However, there are not many available drugs in clinical practice and their effects are slow. [0003] Acetylcysteine, which is N-acetyl-L-cysteine. Acetylcysteine ​​is a mucolytic agent, which has a strong effect of dissolving mucus. Viscosity of sputum and liquefaction. Acetylcysteine ​​can also break DNA fibers in purulent sputum, so it can not only d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K9/12A61P11/00A61K31/09
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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