Medicinal composition of oxymatrine and polysaccharide
A composition and technology of matrine, applied in the field of medicine, to achieve uniform and stable drug quality, reduce relative drug dosage, and ensure safety
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Embodiment 1
[0123] Example 1 Preparation of Ganoderma lucidum polysaccharide
[0124] Take Ganoderma lucidum, crush it into coarse grains, add 4 times the amount of water to moisten overnight, decoct three times the next day, add 12 times the amount of water to decoct for 3 hours for the first time, add 10 times the amount of water for 2 hours, and decoct for the second time Add 10 times the amount of water three times and decoct for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.15, filter, use the Sevage method to remove protein from the filtrate, filter, add ethanol to the filtrate until the alcohol content is 60%, stir well, refrigerate for 24 hours, filter, collect the filter cake, add appropriate amount of water to stir and dissolve, filter, add ethanol to the filtrate until the alcohol content is 85%, stir well, refrigerate for 24 hours, filter After washing, collect the filter cake, add appropriate amount of acetone and ethanol to...
Embodiment 2
[0135] The preparation of embodiment 2 KLX composition powder injection
[0136] 1. Prescription:
[0137]
[0138] 2. Specific steps:
[0139] 1) Firstly, aseptically process the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.
[0140] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.
[0141] 3) Add appropriate amount of water for injection to matrine and mannitol, heat and stir to dissolve, take 70% sterile water for injection, add polysorbate 80, heat and stir to dissolve, then add the prescribed amount of Ganoderma lucidum polysaccharide and shiitake mushroom Polysaccharide, stir to dissolve completely. Combine the above solutions and add sterile water for injection to 5000ml.
[0142] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.
[0143] 5) Decarbonize by filtering through a sand filter rod, measure and adjust the pH value of the s...
Embodiment 3
[0149] Embodiment 3 Preparation of KLX composition aqueous injection
[0150] 1. Prescription:
[0151]
[0152] 2. Specific steps:
[0153] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.
[0154] 2) Add an appropriate amount of water for injection of matrine, heat and stir to dissolve, take 70% sterile water for injection, add polysorbate 80, heat and stir to dissolve, then add the prescribed amount of ganoderma lucidum polysaccharide and lentinan, and stir Dissolve completely. Combine the above solutions and add sterile water for injection to 5000ml.
[0155] 3) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.
[0156] 4) Decarbonize by filtering through a sand filter rod, measure and adjust the pH value of the solution.
[0157] 5) Fine filtration through a 0.45 μm microporous membrane.
[0158] 6) Check the clarity of the ...
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