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Chinese pharmaceutical composition for treating cardiovascular and cerebrovascular disease and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of preparation of the traditional Chinese medicine composition, and can solve the problems that the curative effect needs to be improved, etc.

Active Publication Date: 2009-06-17
张恩德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the medicine made from single Angelica sinensis, such as Angelica sinensis injection, has achieved certain effects in the treatment of cardiovascular and cerebrovascular diseases, the curative effect still needs to be improved. On this basis, it is necessary to develop drugs with more accurate curative effect and more convenient use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Angelica 400g, borneol 30g.

[0030] Take Angelica sinensis medicinal material, pulverize, extract volatile oil by steam distillation, then use saturated hydroxypropyl β-cyclodextrin solution for clathrate of volatile oil to obtain volatile oil clathrate of Angelica sinensis, and set aside; after extracting volatile oil, the residue is heated and extracted with water for 3 Once, the amount of water added is 8 times, 6 times and 4 times of the amount of medicinal materials respectively, for 2 hours each time, the extract is combined, the extract is concentrated to 2 times of the amount of medicinal materials, and then 95% ethanol is added to make the ethanol concentration of the extract reach 80%. Let stand for 24 hours, centrifuge, concentrate the supernatant to a relative density of 1.15, and obtain the Angelica sinensis extract for later use.

[0031] Take angelica volatile oil clathrate, angelica extract and borneol, mix with 350g microcrystalline cellulose evenly, a...

Embodiment 2

[0033] Angelica 400g, borneol 12g.

[0034]Take angelica medicinal material, pulverize, extract with carbon dioxide supercritical, extraction pressure 30MPa, extraction temperature 45°C, extract for 6 hours, extract the volatile oil obtained by inclusion with saturated hydroxypropyl β-cyclodextrin solution to obtain angelica volatile oil Inclusion compound, for later use; the residue after supercritical extraction is heated and extracted 3 times with water, and the amount of water added is 8 times, 6 times and 4 times the amount of medicinal materials, respectively, for 2 hours each time, the extracts are combined, and the extracts are concentrated to 2 times Add 95% ethanol to make the ethanol concentration of the extract reach 70%, let it stand for 24 hours, centrifuge, concentrate the supernatant to a relative density of 1.20, and obtain the angelica extract for later use.

[0035] Take angelica volatile oil clathrate, angelica extract and borneol, mix evenly with 70g polye...

Embodiment 3

[0037] Angelica 400g, borneol 5g.

[0038] Take angelica medicinal material, pulverize, extract with carbon dioxide supercritical, extraction pressure 30MPa, extraction temperature 40°C, extract for 8 hours, extract the volatile oil obtained by inclusion with saturated hydroxypropyl β-cyclodextrin solution to obtain angelica volatile oil Inclusion compound, for later use; the residue after supercritical extraction is heated and extracted 3 times with water, and the amount of water added is 8 times, 6 times and 4 times the amount of medicinal materials, respectively, for 2 hours each time, the extracts are combined, and the extracts are concentrated to 2 times The amount of medicinal materials, then add 95% ethanol to make the ethanol concentration of the extract reach 85%, let it stand for 24 hours, centrifuge, concentrate the supernatant to a relative density of 1.20, get the angelica extract, and set aside; use saturated hydroxypropyl β-ring Dextrin solution is carried out c...

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, which is prepared from the following raw materials (by weight percent): Chinese angelica root 90.0-99.9%, borneol 10.0-0.1%. The invention also discloses the process for preparing the pharmaceutical composition.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, and also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Cardiovascular and cerebrovascular diseases, such as coronary heart disease and cerebral infarction, are the main causes of human disease and death, accounting for one-third of the total mortality rate. In China, the mortality rate has surpassed that of cancer. And along with the improvement of people's living standards in China, the population suffering from cardiovascular diseases is increasing day by day, and the sick and disabled are left among the survivors, which poses a huge life threat to the patients. It also imposes a heavy burden on the patient's family and the whole society. [0003] Angelica, as a traditional blood-enriching medicine, has the functions of nourishing blood and promoting blood circu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/232A61P9/10A61K31/045
Inventor 张恩德
Owner 张恩德