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Novel crystal of triterpene derivative

A technology of crystals and crystal forms, applied in the field of crystals of triterpene derivatives, can solve the problems of not mentioning compound II type crystals, etc., and achieve the effect of inhibiting and reducing

Inactive Publication Date: 2009-07-08
SHIONOGI & CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in Patent Document 4, only ethyl acetate is mentioned as a specific example of an organic solvent, and the type II crystal of compound (I) of the present invention is not mentioned

Method used

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  • Novel crystal of triterpene derivative
  • Novel crystal of triterpene derivative
  • Novel crystal of triterpene derivative

Examples

Experimental program
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Embodiment 1

[0016]

[0017]

experiment Embodiment 1

experiment Embodiment 2

[0018]

[0019]

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Abstract

Disclosed are a novel crystal of a novel triterpene derivative, a method for producing the same and a pharmaceutical drug obtained using such a crystal. Specifically disclosed is a crystal of a compound (I) which is represented by the formula below.

Description

technical field [0001] The present invention relates to new crystals of triterpene derivatives, processes for preparing said crystals and pharmaceutical preparations obtained by using said crystals. Background technique [0002] Compounds of the formula are known: [chemical formula 1] (hereinafter the compound will be referred to as "Compound A"), which is an endothelin receptor antagonist, is used for the treatment of various circulatory diseases such as hypertension, ischemic disorders, cerebral circulation disorders, renal disorders, various organ Insufficient circulation, asthma, stroke, cerebral infarction, cerebral edema, etc. (see Patent Documents 1 and 2). Moreover, the free compound of compound A of formula (I): [chemical formula 2] (hereinafter this compound will be referred to as "compound (I)"), which has been isolated as pale yellow needle-like crystals by using ethyl acetate as a recrystallization solvent (see Non-Patent Document 1). Pate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C233/55A61P9/00A61P9/10A61P9/12A61P11/06A61P13/12A61P25/28A61P43/00C07C231/10A61K31/216C07C231/22
CPCA61K31/216C07C231/22C07J63/008A61P9/00A61P9/10A61P9/12A61P11/06A61P13/12A61P25/00A61P25/28A61P43/00C07C233/55C07C231/10
Inventor 麓昌高
Owner SHIONOGI & CO LTD