Method for extracting total saponin for Chinese herb medicine clinopodium polycephalum

An extraction method and technology of cutting off blood flow, which are applied to the extraction method of total saponins of the traditional Chinese medicine off blood flow and its soft capsules, which can solve the problems of large doses of preparations, poor stability of curative effect, and difficulty in quality monitoring

Inactive Publication Date: 2009-08-05
ANHUI AN TECH MEDICAL & BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the gynecological hemostatic drugs currently available on the market have problems such as poor or inaccurate curative effect stability, some curative effect is acceptable but the effective index components are not clear, the quality is difficult to monitor, and the dosage of the preparation is large.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0053] (1) Extraction of total saponins from blood flow: take 4500 parts of blood flow cut, cut into 2-3cm sections, add 54L of water to soak for 12 hours, extract for 1 hour, filter (through a 200-mesh sieve), centrifuge; Extract with 45L water for 3 times, each time for 1 hour, filter and centrifuge; the extracts are combined, concentrated to a relative density of 1.05 (50°C thermal measurement), and heated on a D-101 macroporous resin column (5000ml); After the active ingredients of the medicinal solution are completely absorbed (the flow rate is adjusted according to the diameter of the column, take 100ml of the effluent and concentrate it on a water bath to dryness, and the residue should be negative in the reaction test of concentrated sulfuric acid-acetic anhydride); color, discard the water washing solution, and wash with 70% ethanol until the eluent does not contain saponin components (the same method as above should be negative); collect the alcohol eluent, recover th...

example 2

[0057] (1) Extraction of total saponins from blood flow: take 4500 parts of blood flow, cut into 2-3cm sections, add 54L of water to soak for 12 hours, extract for 1.5 hours, and filter; extract with 45L of water for 1.5 hours with medicinal residues, and filter; filtrate Combined, concentrated to a relative density of 1.15 (80°C thermal measurement), added ethanol until the alcohol content reached 63%, fully stirred, allowed to stand for 24 hours, took the supernatant, concentrated under reduced pressure into a thick paste, and dried under reduced pressure ( 80°C) into dry extract, crushed into fine powder 256g, set aside;

[0058] (2), take salad oil 322g, beeswax 12g, Span-806g;

[0059] (3) Mix the raw drug fine powder obtained in item (1) with the material obtained in (2), and prepare 1000 soft capsules with the capsule material, each containing the saponin component Budiaoside IV (in the form of high-efficiency liquid phase method) not less than 1.2mg. Usage and dosage...

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PUM

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Abstract

The invention discloses a method for extracting total saponins of the traditional Chinese medicine Duanxueliu and Duanxueliu soft capsules. After the traditional Chinese medicinal materials in Duanxueliu are extracted with water, the water extract is passed through the AB-8 (D-101 type) macroporous resin column to absorb the total saponins in Duanxueliu, elute with 70% ethanol, and recover the ethanol under reduced pressure. Dry under reduced pressure to obtain a fine powder. The total saponins of Duanxueliu are mixed with salad oil, beeswax, Span-80 or liquid polyethylenediamine, solid polyethylenediamine, glycerin, and Span-80 to prepare Duanxueliu soft capsules. It is used to treat hemorrhage, especially gynecological hemorrhagic disease, and has definite curative effect, small dosage and is stable.

Description

technical field [0001] The invention belongs to the extraction and preparation of active ingredients of traditional Chinese medicine, in particular to a method for extracting total saponins of the traditional Chinese medicine blood flow for treating hemorrhagic diseases, especially gynecological hemorrhagic diseases, and soft capsules thereof. Background technique [0002] Among the approximately 500 million women in my country, about 250 million are aged 15-39, and 60-80% of them suffer from menstrual and uterine problems. Especially for married women, taking contraceptives, implementing birth control rings, incubating tube ligation, artificial abortion, induced labor and other measures to implement family planning, coupled with work and family pressure, often trigger functional uterine bleeding, menorrhagia, Menstrual disorders and other diseases, these diseases not only affect life, work and physical health, but also the most important factors affecting skin health and ap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K9/48A61P15/00A61P7/04
Inventor 余世春
Owner ANHUI AN TECH MEDICAL & BIOLOGICAL TECH
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