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Method of preventive treatment of allergy by mucosal administration of an allergy vaccine

An allergic reaction and preventive technology, applied in the direction of allergen antigen components, etc., can solve life-threatening problems

Inactive Publication Date: 2012-11-14
ALK ABELLO SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After each injection, the patient must be under medical supervision for 30 minutes because of the risk of allergic side reactions, which, although extremely rare, can in principle be life-threatening

Method used

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  • Method of preventive treatment of allergy by mucosal administration of an allergy vaccine
  • Method of preventive treatment of allergy by mucosal administration of an allergy vaccine
  • Method of preventive treatment of allergy by mucosal administration of an allergy vaccine

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0115] Example 1: The effect of SLIT on a mouse model of rhinitis

[0116] Fundamental:

[0117] A rhinitis model was established to test the effect of sublingual immunotherapy (SLIT) in a clinically manifested mouse model.

[0118] method:

[0119] animal

[0120] 6-10 week old female BALB / c mice were housed and maintained on a specific diet that did not contain components that could cross-react with antiserum from Timothy grass (Phlp). Each experimental group included 8-10 animals.

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PUM

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Abstract

The present invention relates to a method of preventive treatment of allergy to an allergen in a subject comprising administering an allergy vaccine containing the allergen as active substance to a mucosal surface of the subject, a) wherein the subject to be treated is sensitised so as to exhibit an IgE response specific to the allergen, b) wherein the subject to be treated is free of clinical symptoms of the allergy associated with the allergen, and c) wherein the preventive treatment is aimed at preventing or reducing subsequent clinical symptoms of the allergy associated with the allergen.

Description

field of invention [0001] The present invention relates to a method of prophylactically treating an allergic reaction to an allergen in a subject comprising administering anaphylaxis vaccine to a mucosal surface of the subject. Background of the invention [0002] Allergic reactions are a major health problem in countries adopting a western lifestyle. In addition, the prevalence of allergic diseases is increasing in these countries. Although in general, anaphylaxis is not considered a life-threatening condition, asthma is responsible for a large number of deaths each year. The prevalence of the disorder in about 30% among adolescents results in a significant reduction in quality of life, workday and money, and constitutes a major type of health problem in the Western world. [0003] Anaphylaxis is a complex disease. Allergic events are caused by a variety of factors, including an individual's susceptibility determined by the not-well-understood interplay of several genes....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/35
Inventor J·布里莫奈斯J·基尔德斯加德
Owner ALK ABELLO SA
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