Tissue engineering venous valve and its production

Abstract

The invention is concerned with biology structure process technology field. At present, the foreign research of tissue-engineered venous valvular is on the primary phase, and some problems is not clear and needs to be solved, such as the selection of cell and bracket, growth and adhering of cell and inner process of body. The aim of this invention is to afford tissue-engineered venous valvular replanting substance and the replanting substance is made up of seed cell and bracket. The said seed cell ismultipotent adult progenitor cells (MAPC) andendothelial progenitor cells (EPC), and the said bracket is homogeneity variant acellularized venous with valvular. It also affords the production method of the said tissue-engineered venous valvular. This material is fit for repairing the insufficiency tissue-engineered venous valvular to the deep vein imaging of lower extremity with wide source and without the problem of immunogenicity and ethic. The invention has excellent function and effecton animals.

Description

Tissue engineered venous valve and preparation method thereof technical field The invention relates to the technical field of biological tissue engineering, and relates to a tissue-engineered venous valve and a preparation method thereof. Background technique Venous valve transplantation is often the last option for primary valvular insufficiency, valve destruction after complete recanalization of thrombosis, and congenital valvular deficiency. However, in addition to the limited source and large damage of autologous venous valve transplantation, there are still problems such as insufficient valve strength and the caliber of the valve-bearing vein is often difficult to meet the requirements. In recent years, the development of cardiovascular tissue engineering technology has made it possible to construct tissue engineered venous valves. Studies have shown that although there are many pairs of valves in each deep vein, only one pair of functional valves can significantly i...

AI Technical Summary

Problems solved by technology

So far, there is no report on the joint application of bone marrow-derived MAPC and EPC as seed cells for tissue engineering valves