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Preparation for chemical component of Shenmai injection and application of the same in curing cardio-cerebrovascular disease

A technology of cardiovascular and cerebrovascular diseases and Shenmai injection, applied in the application field of treating cardiovascular diseases, can solve the problems of unclear active ingredients and no significant effect of pharmacological models

Inactive Publication Date: 2007-11-28
CHIATAI QINGCHUNBAO PHARMA
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Problems solved by technology

Shenmai needles have been clinically used for more than 20 years, but the active ingredients in them have been unclear. The current quality standards for Shenmai needles are three ginsenosides Rb1, Rg1 and Re in ginseng (red ginseng), but studies have shown that These three compounds have no significant effect on all existing pharmacological models of cardiovascular and cerebrovascular aspects

Method used

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  • Preparation for chemical component of Shenmai injection and application of the same in curing cardio-cerebrovascular disease
  • Preparation for chemical component of Shenmai injection and application of the same in curing cardio-cerebrovascular disease
  • Preparation for chemical component of Shenmai injection and application of the same in curing cardio-cerebrovascular disease

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Embodiment Construction

[0005] 1. Preparation method of compound

[0006] 1.1 The preparation method of compound I-VIII:

[0007] i.) 10 kg of traditional Chinese medicine Zhejiang Ophiopogon japonicus is prepared into Ophiopogon japonicus stock solution according to the production process of Shenmai injection, concentrated under reduced pressure at 40°C, separated by macroporous resin column chromatography, and eluted with gradient water-alcohol Liquid elution to obtain water, 10%, 20%, 40%, 60%, 80% and 95% ethanol elution fractions of Ophiopogon japonicus stock solution.

[0008] ii.) The 95% ethanol eluted part obtained in i was separated with a silica gel column, and petroleum ether, chloroform, chloroform-acetone (1:0→1:1), chloroform-methanol (50:1→1:1) were used as Developing solvent elution; Chloroform-acetone (20: 1) eluted part continues to separate with silica gel column chromatography, can obtain compound VI with sherwood oil-ethyl acetate (5: 1) as developing solvent purification; Chlo...

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Abstract

The present invention discloses process of extracting and separating compounds I-VIII from ginseng-ophiopogon injection. These compounds have functions of inhibiting myocardial cell apoptosis, promoting the release of CO from vascular endothelial cell, suppressing oxidation caused by AAPH, etc; and this show that these compounds are main active components for the ginseng-ophiopogon injection to treat cardiac and cerebral vascular diseases. The extracting and separating process includes the steps of: chromatographic separation in macroporous resin column, MCI columm, silica gel column, glucosan gel column and reverse silica gel column; efficient liquid phase separation; sublimation; crystallization; etc. The compound structure identification is completed through infrared method, 1D and 2D nuclear magnetic resonance, mass spectrum and other spectroscopic method.

Description

technical field [0001] The invention relates to a preparation method of an active chemical component of a traditional Chinese medicine injection used for treating cardiovascular and cerebrovascular diseases and its application in treating cardiovascular diseases. Background technique [0002] Shenmai Injection (also known as "Shenmai Water Injection", hereinafter referred to as "Shenmai Needle") is a derivative of the ancient prescription "Shengmaisan", which is extracted and processed by modern technology from two Chinese medicinal materials, red ginseng and Radix Ophiopogon japonicus , for the treatment of shock, coronary heart disease, viral myocarditis, chronic pulmonary heart disease, and neutropenia of Qi and Yin deficiency. It is a national protected variety of traditional Chinese medicine and is a basic emergency medicine. Shenmai needles have been clinically used for more than 20 years, but the active ingredients in them have been unclear. The current quality standa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C35/29C07D311/38C07D407/06C07J71/00C07H15/203A61K31/045A61K31/352A61K31/58A61K31/704A61P9/00A61K36/8968
Inventor 朱大元黎豫杭许正宇萧耀龙李云森谭昌恒蒋福祥柯嘉敏文英强张善飞柴建国
Owner CHIATAI QINGCHUNBAO PHARMA
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