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Preventing or treating agent for glaucoma

A therapeutic agent and glaucoma technology, applied in the direction of medical preparations containing active ingredients, active ingredients of phosphorus compounds, organic active ingredients, etc., can solve problems such as limited treatment, and achieve strong intraocular pressure reduction, high preventive or therapeutic effects

Inactive Publication Date: 2007-12-12
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, reducing normal intraocular pressure is more difficult than reducing elevated intraocular pressure. The above-mentioned known drugs and their combinations are limited in the treatment of normal intraocular pressure glaucoma, and clinical treatment urgently needs to further enhance the effect of lowering intraocular pressure

Method used

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  • Preventing or treating agent for glaucoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] To (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methylhomopiperazine-hydrochloride 1.1g, anhydrous sodium dihydrogen phosphate (Taiping Chemical Industry ( Co., Ltd.) 0.8 g and 0.5 g of potassium chloride were added to 50 g of purified water and stirred to dissolve completely. Sodium hydroxide dissolved in purified water was added to adjust the pH to 6.7, and further purified water was added to make the total amount 100 g. In addition, the osmotic pressure was 348 mOsm / Kg.

Embodiment 2

[0047] Anhydrous sodium dihydrogen phosphate is 0.6 g, and eye drops are prepared in the same manner as in Example 1. In addition, the osmotic pressure was 332 mOsm / Kg.

Embodiment 3

[0049] Anhydrous sodium dihydrogen phosphate was 0.4 g, and eye drops were prepared in the same manner as in Example 1. In addition, the osmotic pressure was 315 mOsm / Kg.

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PUM

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Abstract

The present invention provides a glaucoma preventive or therapeutic agent having a strong intraocular pressure-lowering effect and sufficient intraocular pressure-lowering effect even for normal intraocular pressure. Provides a preventive or therapeutic agent for glaucoma, high Preventive or therapeutic agents and eye drops for intraocular hypertension.

Description

technical field [0001] The present invention relates to a preventive or therapeutic agent for glaucoma containing (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methylhomopiperazine or a salt thereof. Background technique [0002] Normally, the aqueous humor circulates continuously in the eyeball to maintain a certain intraocular pressure. However, the flow of aqueous humor in the line-dimensional column of the outlet gradually decreases, or the corners become narrower. When the flow of aqueous humor is blocked, the intraocular pressure in the eyeball will rise, and the result will be oppression of the optic nerve. Glaucoma that causes visual field abnormalities, or ocular hypertension that is not accompanied by visual field abnormalities but has a high possibility of developing glaucoma over a long period of time. In order to treat this glaucoma or ocular hypertension, it is necessary to lower the elevated intraocular pressure. In actual clinical treatment, sympathetic sti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/551A61K33/42A61P27/06
CPCA61K31/551A61K33/42A61P27/00A61P27/02A61P27/06A61P43/00A61K2300/00
Inventor 杉本信水野宪高桥正寿金箱真
Owner KOWA CO LTD
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