Omega-3 fatty acids and dyslipidemic agent for lipid therapy

A technology of dyslipidemia and fatty acid, applied in the field of omega-3 fatty acid and dyslipidemia agent for blood lipid treatment

Inactive Publication Date: 2008-01-02
RELIANT PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0038] Combinations of omega-3 fatty acids with other fibrates such as gemfibrozil and clofibrate have not been shown to produce any unexpected synergistic effects in the treatment of hyperlipidemia and hyperlipoproteinemia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0093] Omacor 4 grams per day has been reviewed  Effects of omega-3 fatty acids on lipid parameters, namely triglyceride levels (TG), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). The Omacor  Omega-3 fatty acids are provided in liquid-filled gel capsules for oral administration. Omacor per gram  The capsules contain at least 900 mg of ethyl esters of omega-3 fatty acids, mainly comprising eicosapentaenoic acid (EPA) (about 465 mg) and docosahexaenoic acid (DHA) (about 375 mg). As shown in Table 1, Omacor  The efficacy of omega-3 fatty acids depends on the baseline TG levels of the treated patients.

[0094] Table 1 Administration of Omacor  Percent change in lipid parameters in patients after monotherapy

[0095] baseline

TG (mg / dL)

TG

total cholesterol

HDL

LDL

VLDL

non-HDL

0-199

-22.5

3.5

5.2

10.7

-31.6

...

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PUM

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Abstract

A method and composition for blood lipid therapy that comprises administering to the subject an effective amount of a PPAR agonist and / or antagonist and an omega-3 fatty acid. The methods and compositions include combination products or concomitant therapy for the treatment of subjects with hypertriglyceridemia, hypercholesteremia, mixed dyslipidemia, vascular disease, a rtheroscl erotic disease and related conditions, obesity, the prevention or reduction of cardiovascular and vascular events, the reduction of insulin resistance, fasting glucose levels and postprandial glucose levels, and / or the reduction of incidence and / or the delay of onset of diabetes.

Description

[0001] This application claims from Serial No. 60 / 633,125 filed December 6, 2004, Serial No. 60 / 659,099 filed March 8, 2005, and Serial No. 60 / Priority to provisional patent application 699,866. The disclosure of said provisional application is incorporated herein by reference. technical field [0002] The present invention relates to the treatment of patients with hypertriglyceridemia, coronary heart disease (CHD), vascular disease, arteriosclerosis ( arterosclerotic disease) and related conditions, and methods of preventing or reducing cardiovascular and vascular disease. Background technique [0003] In humans, cholesterol and triglycerides are part of lipoprotein complexes in the bloodstream that can be separated by ultracentrifugation into high-density lipoproteins (HDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL ) and very low-density lipoprotein (VLDL) fraction. Cholesterol and triglycerides are synthesized in the liver, combined into ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/225
CPCA61K31/202A61K31/192A61K31/426A61K31/22A61K45/06A61P3/04A61P3/06A61P3/08A61P3/10A61P9/00A61P9/10A61K2300/00
Inventor 鲁洛夫·M.·L.·龙根乔治·博博泰斯
Owner RELIANT PHARMACEUTICALS INC
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