Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases

An immunomodulation, compound technology, applied in the prevention and/or control of various parasitic diseases and disorders, pharmaceutical compositions and dosage forms, in the field of treatment, can solve the adverse effects of chemotherapeutic agents, ineffective treatment of parasitic diseases and other problems

Inactive Publication Date: 2008-01-02
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, chemotherapeutic agents commonly used to treat various parasitic diseases have adverse effects
Although adaptive immunotherapy has demonstrated some benefit, it is far from providing an effective treatment for parasitic diseases

Method used

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  • Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
  • Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
  • Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases

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Embodiment Construction

[0013] A first embodiment of the invention includes a method of treating, controlling, or preventing a parasitic or protozoan disease or condition comprising administering to a patient in need of such treatment or prevention a therapeutically or prophylactically effective amount of an immunomodulatory compound of the invention, or a pharmaceutically acceptable salt, solvate, stereoisomer, or prodrug thereof.

[0014] In particular methods encompassed by this embodiment, the immunomodulatory compound is administered in combination with another drug ("second active agent") or method of treating, controlling, or preventing a parasitic or protozoan disease or condition. Second active agents include small molecules and large molecules (eg, proteins and antibodies), examples of which are provided herein.

[0015] The invention also includes pharmaceutical compositions (eg, single unit dosage forms) useful in the methods disclosed herein. Particular pharmaceutical compositions compr...

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PUM

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Abstract

Methods of treating, preventing and / or managing various protozoan parasitic disease and disorders are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone, or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with conventional anti-parasitic treatments which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Description

1. Field of invention [0001] The present invention relates to methods of treating, preventing and / or managing various parasitic diseases and conditions using immunomodulatory compounds. The invention also relates to pharmaceutical compositions and dosage forms. 2. Background of the invention [0002] 2.1 Parasitic and protozoan diseases [0003] Intracellular protozoan parasitic diseases can be difficult to treat. The reported efficacy and safety of known treatments vary, depending on many factors, such as route of administration and severity of the disease. [0004] Malaria is one such disease, caused by blood protozoa of the Plasmodium species, four of which are known to infect humans. More than 270 million people live with the disease, and 1.2 to 1.7 million people die from it each year. The mortality rate was reported to be higher among children under 5 years of age. Ziffer et al., Progress in the Chemistry of Organic Natural Products, Herz W Ed., 1997, pp. 121-214....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4035A61P33/02A61K45/00A61P33/06A61K31/45A61P33/12
CPCA61K45/06A61K31/655A61K31/65A61K31/45A61K31/4035A61K31/63A61K31/496A61K31/7048A61K31/573A61K31/29A61P33/00A61P33/02A61P33/06A61P33/10A61P33/12A61K2300/00A61K45/00
Inventor 詹尼弗·L·汉森
Owner CELGENE CORP
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