Preparation for biological wound-surface filling drainage used for hemorrhoid resection operation and using method

A drainage and wound technology, which is applied in the preparation and use of biological wound filling drainage for hemorrhoidectomy, and can solve problems such as edema, anal canal stenosis, and slow wound healing

Inactive Publication Date: 2008-02-20
杨新庆 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the postoperative recurrence rate can reach about 10%. In addition, anal edema and pain are prone to occur a

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Application of fresh porcine dermal tissue to prepare biological wound filling drainage for hemorrhoidectomy

[0030] Collect fresh porcine dermal tissue and cut into 1-3cm 3 Small pieces were immediately fixed with 2% formaldehyde solution for 2 to 4 hours, and washed several times with distilled water. Then, the tissue was incubated with 1N sodium hydroxide solution at a constant temperature of 20°C for 24 hours for decellularization. Then, the tissue was washed with sodium phosphate buffer until the tissue became translucent. Then the washed tissue was incubated in glycine-HCl buffer to eliminate residual fixative and lower the pH value until the pH value was 7.35-7.55.

[0031] Soak the treated tissue in a homogeneous aqueous solution of mixed 50 mg / ml gentamicin sulfate and 50 mg / ml metronidazole, take it out after 10 minutes, dry it, and then soak the tissue in 50 mg / ml dodecane The solution is dried and pulverized, and the prepared mold is used to p...

Embodiment 2

[0032] Embodiment 2: Surgical method is filled into hemorrhoid wound filling drainage

[0033] 1. Traditional external stripping and internal ligation or hemorrhoidectomy to remove hemorrhoids.

[0034] 2. Pre-cut the hemorrhoid biological wound filling and drainage material prepared in Example 1 into a suitable size with scissors according to the specific conditions in the operation, and cut out a narrow strip with a width of 1-4 cm on one side to be used as a drainage strip.

[0035] 3. Fill the cut biological wound filling and drainage into the submucosal wound, and pay attention to spreading it neatly. The incised mucosal tissue was sutured.

[0036] 4. Lead the drainage strip through the skin incision below the dentate line.

[0037] 5. Remove the excess part of the tip of the drainage strip, so that the tip of the hemorrhoid wound filling drainage is parallel to the skin.

[0038] 6. Place a iodophor cotton ball and a hemorrhoid suppository in the anus, and change the...

Embodiment 3

[0039] Embodiment 3: curative effect

[0040] Case selection: A total of 40 cases of hemorrhoid patients were selected from June 2006 to October 2007, including 20 cases of III degree internal hemorrhoids, 15 cases of IV degree internal hemorrhoids, and 5 cases of mixed hemorrhoids. Apply the hemorrhoid wound filling and drainage material prepared in Example 1, and use the method provided in Example 2 for treatment. In the control group, 40 cases, all of which were patients with internal hemorrhoids of grade III to IV, were treated with Milligan-Morgan surgery. After follow-up, the results are as follows:

[0041]1. Postoperative pain: 19 cases of the tamponade and drainage group provided by the present invention had no pain (49.5%) on the day after the operation, and 21 cases had anal pain after the operation, and 9 cases (22.5%) of them used analgesic drugs. Patients in the control group had different degrees of anal pain after operation, and 32 cases (80%) were treated wi...

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Abstract

The present invention relates to a preparation method of drain of biological wound surface plugging applied in the hemorrhoids operation and the application. The drain of biological wound surface plugging is made from human or animal skin tissue as the material, preparing in the procedures of fixing, cell extraction and coating with antibiotic layer; the drain of biological wound surface plugging is plugged in the wound surface below the die sticking after the hemorrhoids operation; thus, the drain of biological wound surface plugging can effectively advance the concrescence of the wound surface and the incident ratio of complication after operation is reduced.

Description

technical field [0001] The invention relates to a preparation method and application of a biological wound filling drainage material used for hemorrhoidectomy. The bio-wound filling drainage is prepared by using human or animal skin tissue as raw material through fixation, decellularization, introduction of antibiotic coating and other steps, and is surgically filled into the submucosal wound after surgical resection of hemorrhoid tissue. Effectively promote wound healing and reduce the incidence of postoperative complications. Background technique [0002] The hemorrhoids described in this specification are pathological changes and (or) abnormal displacement of the supporting structure of the anal cushion (anal canal vascular cushion), vascular plexus and arteriovenous anastomotic branches, which can lead to a series of clinical symptoms such as bleeding and prolapse. The "anal cushion" refers to the thickened submucosal tissue in the dentate line region, which contains a ...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L31/14
Inventor 杨新庆王振军杨晓东陈朝文赵博
Owner 杨新庆
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