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Methods of treating ear infections

A technology of otitis media, antimicrobial agent, applied in the field of ear infection treatment, which can solve the problem without causing systemic effects

Inactive Publication Date: 2011-01-12
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This usually results in little or no systemic effects

Method used

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  • Methods of treating ear infections
  • Methods of treating ear infections
  • Methods of treating ear infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0380] Antimicrobial compositions were prepared using the components shown in Table 1. The components were combined and heated to give a clear solution that remained clear on cooling to room temperature. These solutions were used for further antimicrobial testing.

[0381]

[0382] NA - not applicable

[0383] *These components can also function as penetrants.

Embodiment 5

[0384] Example 5 - Testing MIC using Streptococcus pneumoniae type 3

[0385] Minimum inhibitory concentrations were determined using agar dilutions according to procedures such as those described in National Committee for Clinical Laboratory Standards (1993); Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically-Third Edition: Approved Standard M1-A3. NCCLS, Villanova, PA (MIC). Decade dilutions from 1 / 10 to 1 / 10,000 were prepared for all compounds. The compositions of Examples 1-4 had MICs in the 1 / 1000 dilution range.

[0386] A second experiment was performed starting from a 1 / 100 dilution of each compound and measuring CFU / mL of the different dilutions. The results of those tests for 1 / 100, 1 / 500, 1 / 1000, and 1 / 5000 dilutions of each example solution are provided in Tables 2a-d below. The initial inoculation was 1×10 6 / mL organism. The samples were incubated at 37° C. in an incubator with 7% carbon dioxide and fixed. The concent...

Embodiment 6

[0392] Example 6. MIC test with Haemophilus influenzae

[0393] Bacterial kill was determined as described in Example 5, however, the organism used was atypical Haemophilus influenzae in Todd Hewitt's medium supplemented with NAD and Hemin. Example formulations 1, 2, and 4 were tested and the results are provided in Tables 3a-c below.

[0394]

[0395]

[0396]

[0397] Tables 3a-c show example formulations effective in killing atypical H. influenzae.

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Abstract

Methods of treating and / or preventing otitis media in a subject are provided. Methods of treating and / or preventing otitis externa are also provided.

Description

[0001] related application [0002] This application claims priority to US Provisional Patent Application 60 / 660,593, filed March 10, 2005, which is incorporated herein by reference. Background technique [0003] Most ear infections are characterized by inflammation. Typically, this condition known as "otitis" is diagnosed and treated to reduce the risk of conditions such as hearing loss, tinnitus, facial nerve palsy, mastoiditis, otitis interna, vertigo, and encephalitis. Most ear infections affect the outer or middle ear. [0004] Otitis externa (infection of the outer ear) is primarily caused by bacterial infections (such as Staphylococcus intermedinus, Streptococcus spp., Pseudomonas spp., Proteus spp., and Escherichia coli caused by Escherichia coli). Typically, low concentrations of bacteria are present in the external auditory canal, and their growth is mainly inhibited by the weakly acidic pH and the formation of cerumen (cerumen). Open wounds left by patients with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/23A61K31/231A61K31/075A61K31/215A61K31/045A61K31/19A61K31/20A61P27/16A61P31/00
CPCA61K31/19A61K31/231A61K31/215A61K31/20A61K31/075A61K31/23A61K31/045A61P27/16A61P31/00A61P31/02A61K2300/00
Inventor 马修·T·斯科尔茨王丹黎杰弗里·F·安德鲁斯
Owner 3M INNOVATIVE PROPERTIES CO