Preparing technique for separating and purifying rosmarinic acid by big-hole adsorption resin

A technology for rosmarinic acid and preparation process, which is applied in the field of biochemistry and can solve problems such as large loss and complex process

Inactive Publication Date: 2008-03-12
TIANJIN UNIV OF SCI & TECH
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Problems solved by technology

However, the whole process is relatively complicated, and the relative loss is relatively large in the refining process.

Method used

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  • Preparing technique for separating and purifying rosmarinic acid by big-hole adsorption resin

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Embodiment Construction

[0022] The present invention is further described in detail through the following examples, but the technical content described in this example is illustrative rather than limiting, and should not limit the protection scope of the present invention accordingly.

[0023] The macroporous adsorption resins adopted in the present invention are respectively: polar macroporous adsorption resin (NK109 and its homogeneous resin), weakly polar macroporous adsorption resin (AB-8 and its homogeneous resin), nonpolar macroporous Pore ​​adsorption resin (D4006 or D4020 and its homogeneous resin). The present invention is described only by taking polar macroporous adsorption resin (NK109) as an example, and the working modes of other macroporous adsorption resins are basically the same as NK109.

[0024] (1). Preparation of raw materials: The raw materials used in the present invention are plant raw materials containing rosmarinic acid, including higher dicotyledonous plants belonging to La...

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Abstract

The present invention relates to a production process of the rosmarinic acid by absorbing the resin with a large hole, separation and purification of the plant containing the rosmarinic acid. The key technical points are: the plant containing the rosmarinic acid is used as the raw material; the extraction liquid is absorbed with a large hole, purified, eluted and vacuum dried to get the refined rosmarinic acid product. The purity of the product can reach above 90 percent. The present invention successfully uses the macroporous absorption technology of the resin in the one-step refinement, separation and purification of the rosmarinic acid. The rosmarinic acid produced in the present invention has the good antioxidant properties; the pharmacological effects of the rosmarinic acid are relatively strong; the effects of the immune inhibition, microbial inhibition, anti-inflammation, anti-thrombotic and anti-platelet aggregation, anti-allergic and other performances are significant. The present invention provides the possibility for the refining production of the large-scale industrialization of the rosmarinic acid product with the high biological activity, and lays the foundation for the further development and the wide application of the active product.

Description

technical field [0001] The invention relates to the field of biochemistry, in particular to a preparation process for separating and purifying rosmarinic acid from plants containing rosmarinic acid with a macroporous adsorption resin. Background technique [0002] Rosmarinic acid (RosA) is a natural multifunctional phenolic acid compound with certain physiological activities. It was first discovered by Ellis from the rosemary (Rosmarnus officinalis L) plant, so it got its name. In 1958, its structure was determined by Scarpati and Oriente for the first time by chemical degradation. RosA is a dimeric derivative of caffeic acid, the molecular formula is: C 18 h 16 o 8 , whose chemical name is [R(E)]α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxyphenylpropane acid, its chemical structure is: [0003] [0004] It can be seen from the molecular structural formula that the number of phenolic hydroxyl groups and the number of hydrogen bonds that can be forme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/56
Inventor 吕晓玲周平姚秀玲
Owner TIANJIN UNIV OF SCI & TECH
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