ERK2 combination polypeptide and preparation thereof
A technology that combines polypeptides and polynucleotides, applied in the field of polypeptides, can solve the problems of not finding FRS2, etc., and achieve the effect of enhancing FGF pathway and inhibiting activation
Inactive Publication Date: 2010-12-01
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Problems solved by technology
However, previous work did not find the exact binding site of ERK2 on FRS2
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The present invention relates to a polypeptide which has the function of regulating the cell proliferation and differentiation. The present invention provides a separated ERK2 combined polypeptide, which is the polypeptide or the conservative variation polypeptide which has an amino acid sequence of SEQIDNO: 1. the present invention further provides a preparation method of the polypeptide. The polypeptide can be combined with ERK2 (Extracellular signal-regulated kinase2) to regulate the cell proliferation and differentiation, and the disclosure of the polypeptide site provides a new targeted inhibition site for an FGFR inhibitor.
Description
ERK2 binding polypeptide and its preparation technical field The present invention relates to a polypeptide, in particular to a polypeptide with functions of regulating cell proliferation and differentiation and its preparation. Background technique Adaptor proteins are a group of molecular regulators that can recruit different proteins to form complexes and transmit information from upstream signaling molecules (PawsonT, et al. Signaling through scaffolding, anchoring, andadaptor proteins. Science, 19, 2075-80, 1997; Ravichandran KS, et al. .SignalingviaShcfamilyadapterproteins.Oncogene, 20(44), 6322-30, 2001). During the formation of signal transduction complexes and the completion of their biological functions, adaptor proteins often undergo tyrosine phosphorylation, structural changes and subcellular localization changes (ChengY, et al. 19382-19388, 2002; GuriTzivion, et al. 14-3-3 proteins: Active cofactors incellular regulation byserine / threonine phosphorylation. J....
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IPC IPC(8): C07K19/00C07K14/435C12N15/12C12N15/63C12N1/21C12P21/02
Inventor 陈正军周文超
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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