Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

ERK2 combination polypeptide and preparation thereof

A technology that combines polypeptides and polynucleotides, applied in the field of polypeptides, can solve the problems of not finding FRS2, etc., and achieve the effect of enhancing FGF pathway and inhibiting activation

Inactive Publication Date: 2010-12-01
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, previous work did not find the exact binding site of ERK2 on FRS2

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • ERK2 combination polypeptide and preparation thereof
  • ERK2 combination polypeptide and preparation thereof
  • ERK2 combination polypeptide and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a polypeptide which has the function of regulating the cell proliferation and differentiation. The present invention provides a separated ERK2 combined polypeptide, which is the polypeptide or the conservative variation polypeptide which has an amino acid sequence of SEQIDNO: 1. the present invention further provides a preparation method of the polypeptide. The polypeptide can be combined with ERK2 (Extracellular signal-regulated kinase2) to regulate the cell proliferation and differentiation, and the disclosure of the polypeptide site provides a new targeted inhibition site for an FGFR inhibitor.

Description

ERK2 binding polypeptide and its preparation technical field The present invention relates to a polypeptide, in particular to a polypeptide with functions of regulating cell proliferation and differentiation and its preparation. Background technique Adaptor proteins are a group of molecular regulators that can recruit different proteins to form complexes and transmit information from upstream signaling molecules (PawsonT, et al. Signaling through scaffolding, anchoring, andadaptor proteins. Science, 19, 2075-80, 1997; Ravichandran KS, et al. .SignalingviaShcfamilyadapterproteins.Oncogene, 20(44), 6322-30, 2001). During the formation of signal transduction complexes and the completion of their biological functions, adaptor proteins often undergo tyrosine phosphorylation, structural changes and subcellular localization changes (ChengY, et al. 19382-19388, 2002; GuriTzivion, et al. 14-3-3 proteins: Active cofactors incellular regulation byserine / threonine phosphorylation. J....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07K19/00C07K14/435C12N15/12C12N15/63C12N1/21C12P21/02
Inventor 陈正军周文超
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com