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Methods and compositions for assessment of pulmonary function and disorders

A pulmonary disease, coding technology, applied in the direction of biochemical equipment and methods, microbial determination/examination, etc., can solve the problems of not preventing dyspnea, not significantly changing the natural history of OCOPD, respiratory failure, etc.

Inactive Publication Date: 2008-05-14
SYNERGENZ BIOSCIENCE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Despite advances in the treatment of airway disease, current treatments have not significantly altered the natural history of OCOPD, a progressive loss of lung function leading to respiratory failure and death
Although it is expected that cessation of occupational exposure will reduce this decline in lung function, it is likely that if this is not achieved early on, the loss of lung function will be significant and probably will not prevent the worsening of dyspnea symptoms

Method used

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  • Methods and compositions for assessment of pulmonary function and disorders
  • Methods and compositions for assessment of pulmonary function and disorders
  • Methods and compositions for assessment of pulmonary function and disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0298] Case association study

[0299] method

[0300] Symbolic call

[0301]Identify European subjects who have been exposed to long-term smoking (minimum 15 pack years) and air pollutants (hazardous dust or smoke) in the work environment from the respiratory clinic. After testing the vital capacity, enlist those subjects with chronic obstructive pulmonary disease (COPD), whose forced expiratory volume (FEV1) within one second accounts for less than 70% of the predicted value, FEV1 / FVC (forced expiratory volume within one second / Forced vital capacity) ratio <79% (measured using American Thoracic Society standard). 139 subjects were recruited, 70% of whom were male, the average FEV1 / FVC (± standard error) was 54% (SD 15), and the average FEV1 as a percentage of the predicted value was 46 (SD 19). The average age, number of cigarettes per day and annual pack history were 62 years old (SD 9), 25 cigarettes per day (SD 16) and 53 pack years (SD 31), respectively. We also studied 11...

Embodiment 2

[0454] Table 21 below shows representative examples of polymorphisms in linkage disequilibrium with the polymorphisms described herein. Examples of these polymorphisms can be located using public databases, such as www.hapmap.org . The described polymorphisms are shown in parentheses.

[0455] Table 21: Polymorphisms reported to be in linkage disequilibrium (LD) with the polymorphism described in this article

[0456] COX2

[0457] rs7527769

rs689465

rs4648270

rs7550380

rs12027712

rs12759220

rs2206594

rs689466

rs20430

rs6687495

rs2745558

rs4648271

rs6681231

rs3918304

rs11567825

rs13376484

rs20415

rs4648273

rs12064238

rs20416

rs16825748

rs10911911

rs4648254

rs4648274

rs12743673

rs11567815

rs16825745

rs10911910

rs20417(-765G>C)

rs20432

rs12743516

rs20433

rs10911909

...

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PUM

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Abstract

The present invention provides methods for the assessment of risk of developing occupational chronic obstructive pulmonary disease (OCOPD) in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing OCOPD. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided.

Description

Technical field [0001] The present invention relates to a method for evaluating lung function and / or disease using genetic polymorphism and altered gene expression analysis, in particular to evaluating the risk of occupational chronic obstructive pulmonary disease (OCOPD) in smokers and non-smokers Methods. The invention also relates to the application of genetic polymorphism in assessing the risk of OCOPD in a subject. Background technique [0002] Occupational chronic obstructive pulmonary disease (OCOPD) is the result of long-term exposure to multiple substances or air pollutants in the workplace that has been fully understood and studied. The American Thoracic Society (American Thoracic Society) recently released a document on the occupational influencing factors of COPD, which estimates that 15% of COPD is work-related and costs US$7 billion per year [1]. OCOPD is listed as the second leading cause of death due to occupation and it is confirmed that it is still rising [2]. ...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor R·P·扬
Owner SYNERGENZ BIOSCIENCE LTD
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