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Composition of ligustrazine and acanthopanax senticosus concrete as well as application in the preparation of anti-cardiovascular medicament thereof

A technology of cardiovascular and cerebrovascular and Acanthopanax senticosus, which is applied in the fields of cardiovascular system diseases, drug combination, ointment delivery, etc., can solve the problems that there are no reports of drugs for treating cardiovascular and cerebrovascular diseases with Ligustrazine and Acanthopanax senticosus extract composition

Active Publication Date: 2008-05-21
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above two unilateral preparations have been widely used clinically, but so far there has been no report on the combination of Ligustrazine and Acanthopanax Radix Extract being used in the treatment of cardiovascular and cerebrovascular diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Take 0.5 g of Ligustrazine Phosphate, add water for injection to dissolve, take 37 g of Acanthopanax Radix Extractum and dissolve it with Water for Injection, combine the two parts of the solution, and configure it into 1000 ml of liquid medicine according to the conventional method, and obtain the product with a ratio of 1:74 combination.

Embodiment 2

[0012] Example 2: Take 1 g of Ligustrazine Phosphate, dissolve it in water for injection, take 45 g of Acanthopanax Radix Extractum and dissolve it in water for injection, combine the two parts of the solution, and configure it into 1000 ml of liquid medicine according to the conventional method to obtain a combination with a ratio of 1:45 things.

Embodiment 3

[0013] Example 3: Take 5 g of Ligustrazine Phosphate, add water for injection to dissolve, take 55 g of Acanthopanax Radix Extractum and dissolve it with Water for Injection, combine the two parts of the solution, and configure it into 1000 ml of liquid medicine according to the conventional method to obtain a combination with a ratio of 1:11 things.

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PUM

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Abstract

The invention discloses a composite of ligustrazine and acanthopanax extract and the application thereof in preparing drugs for cardio / cerebrovascular disease, with the weight ratio that the ligustrazine: the acanthopanax extract is 1:1 to 200. Being proven by a rat test, the composite is capable of prolonging the time of resisting anoxia of the rat and reducing the water content of the brain. The composite has remarkable effects in resisting the cardio / cerebrovascular disease, and the curative effect is more remarkably advantageous than that of ultra-component medicine.

Description

technical field [0001] The invention relates to a composition of ligustrazine and Acanthopanax japonicus extract and its application in the preparation of cardiovascular and cerebrovascular drugs. technical background [0002] Ligustrazine is an alkaloid extracted from the traditional Chinese medicine Ligusticum Chuanxiong, and its chemical structure is tetramethylpyrazine. Modern pharmacological studies have shown that ligustrazine has anti-platelet aggregation and de-aggregation, expands arterioles, improves microcirculation, enhances cerebral blood flow, and promotes blood circulation and removes blood stasis. It can be absorbed and excreted quickly, and can pass through the blood-cerebrospinal fluid barrier. It is mainly used for ischemic cerebrovascular diseases, such as cerebral insufficiency, cerebral thrombosis, and cerebral embolism. [0003] Acanthopanax is the dried root, rhizome or stem of Acanthopanax acanthopanax, which has the effects of nourishing Qi, invigo...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61K9/06A61P9/10A61K31/4965
Inventor 孙田江陆宏国魏大鹏吴沉尹必喜
Owner YANGTZE RIVER PHARM GRP CO LTD
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