Citrinin biological synthesis gene cluster

Abstract

The invention discloses a biosynthesis gene cluster of Citrinin, which belongs to the microorganism gene technology area. The invention provides ten genes which are related to the biosynthesis Citrinin. The genes are nine modification genes of Citrinin which are ctnD, ctnE, ctnF, ctnG, ctnH, ctnI, orf2, orf3, orf4 and a regulation gene of Citrinin which is ctnR1. The genes, proteins and the antibodies provided by the invention can be used for the detection and development of the compound and protein which are used in medicine, industry and agriculture areas. The invention also provides a way for blocking the biosynthesis of Citrinin.

Description

technical field [0001] The invention relates to the biosynthesis of citrinin, belongs to the technical field of microbial genes, in particular to the biosynthesis gene of citrinin. technical background [0002] Monascus (Monascus, also known as Monascus) has been used in food and traditional Chinese medicine for thousands of years. Modern research has found that Monascus can produce a variety of physiologically active substances. These physiologically active substances are mainly metabolites of Monascus, including antibacterial active substances (such as: monascorubrin), hypotensive substances (such as: γ-aminobutyric acid, acetylcholine), hypoglycemic substances, anti-cancer substances, antioxidant substances, Ergosterol, long-chain fatty acids, cholesterol synthesis inhibitors (eg monacolin), etc. Therefore, the research, development and application of Monascus have been highly valued in recent years. [0003] However, in addition to the beneficial physiologically active...

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Problems solved by technology

[0008] However, the genes involved in citrinin biosyn

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