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Medicinal composition for treating heat heart failure and preparation method and application thereof

A composition and drug technology, applied in the field of pharmaceutical compositions for the treatment of heart failure, can solve the problems of attenuation and efficiency enhancement, compatible use, uncertain parts, etc., and achieve the effect of clear drug effect and low toxicity

Inactive Publication Date: 2011-06-08
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reports are all large prescription preparations containing aconite and dried ginger, and there is no report on the compatibility of only using aconite and dried ginger, and because the medicinal ingredients in aconite and dried ginger are complex, the parts of the ingredients that exert their medicinal effects are not sure. At present, there is no report on the use of effective parts in combination to achieve attenuation and efficiency enhancement.

Method used

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  • Medicinal composition for treating heat heart failure and preparation method and application thereof
  • Medicinal composition for treating heat heart failure and preparation method and application thereof
  • Medicinal composition for treating heat heart failure and preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 The preparation method of medicine of the present invention

[0025] Take 100g of raw aconite and 100g of dried ginger, add 10 times the amount of water to decoct, boil and decoct for 6 hours, pour out the supernatant, filter, then concentrate to the equivalent of 1g aconite per ml, add starch to granulate, add stearic acid Magnesium, pressed into tablets, got tablets.

Embodiment 2

[0026] Embodiment 2 The preparation of medicine of the present invention

[0027] Get raw aconite 500g, dry ginger 200g, extract by the method for embodiment 1, granulate, pack into capsule, obtain capsule.

Embodiment 3

[0028] Embodiment 3 The preparation of medicine of the present invention

[0029] Get raw aconite 100g, dry ginger 200g, extract by the method for extracting conventional medicinal materials or the method of embodiment 1, granulate, pack into capsules, obtain capsules.

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PUM

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Abstract

The invention provides a pharmaceutical composition for the treatment of heart failure, which is the medicament that is prepared of the raw materials with the following mixing ratio by weight: 1 to 5 parts of the total alkaloid of prepared common monkshood daughter root and 1 to 2 parts of the effective part of dried ginger, and the effective part of the dried ginger is dried ginger extract and dried ginger volatile oil. The invention also provides the preparation method and the usage of the pharmaceutical composition. The total alkaloid of the prepared common monkshood daughter root is not only the main toxic component of the prepared common monkshood daughter root, but also is the main effective component of the prepared common monkshood daughter root to play the effect of reviving yangfor resuscitation, and the toxicity-activity relationship is unusually close. When the compatibility of the total alkaloid of the prepared common monkshood daughter root and the dried ginger extract is 2:1, and the compatibility of the total alkaloid of the prepared common monkshood daughter root and the dried ginger volatile oil is 1: 1, the invention has the effect of reducing toxicity and increasing efficacy. The efficacy is exact, the toxicity is low, and the invention provides a new choice for the clinic.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating heart failure, which belongs to the field of medicines. Background technique [0002] Aconite combined with dried ginger is a frequently used antidote in traditional Chinese medicine in ancient and modern times. Aconite dried ginger decoction was first seen in "Treatise on Febrile Diseases·Taiyang Diseases". Aconite is pungent and warm, and the "Book of Materia Medica" says: "It tastes pungent and warm, and the fire is rapid. It warms the heart and restores the yang, which can invigorate the heart yang. It is omnipresent, so it is the first product of returning to yang and rescuing the adversity. Medicine." Dried ginger is pungent and warm, and "Treatise on Drug Properties" says that it "can remove severe cold". Precisely because aconite goes away but does not keep it, and dried ginger keeps but does not go away, the two complement each other very strongly, and the ancients also said t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P9/04
Inventor 彭成郭力曹小玉曾代文唐劲松余葱葱
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE